Role of the nitric oxide on rosuvastatin-induced relaxation of the calf cardiac vein during cooling

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dc.contributor.authorGuresir, M. S.
dc.contributor.authorAtalik, Nurullahoglu K. E.
dc.date.accessioned2024-02-23T14:37:58Z
dc.date.available2024-02-23T14:37:58Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractObjective: 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors including rosuvastatin do not only lower plasma cholesterol but also have non-cholesterol lowering effects on the vessel wall, which decrease cardiovascular complications. The aim of the present study was to evaluate the effect of cooling (to 28 degrees C) on the vasodilatation induced by rosuvastatin (10(-9)-3x10(-4)M) on serotonin-pre-contracted calf cardiac vein and the role of nitric oxide in these effects. Material and methods: Ring preparations of veins obtained from calf hearts were suspended in organ baths containing 25 ml of Krebs-Henseleit solution, maintained at 37 degrees C and continuously gassed with 95% O-2-5% CO2. After a resting period, preparations were contracted with serotonin (10(-6) M) at 37 degrees C. Results: Rosuvastatin produced concentration-dependent relaxation of calf cardiac vein precontracted with serotonin (10(-6) M). During cooling, the pIC(50) value, but not the maximal response, to rosuvastatin was significantly higher than at 37 degrees C. Cooling to 28 degrees C in the presence of N-G-nitro-L-arginine methyl ester (L-NAME, 10(-4) M) decreased the pIC(50) values to rosuvastatin. Conclusion: The results of the present study suggested that nitric oxide played an essential role in the cooling-induced changes of rosuvastatin in calf cardiac vein (Fig. 1, Ref. 23). Text in PDF www.elis.sk.en_US
dc.identifier.doi10.4149/BLL_2014_145
dc.identifier.endpage756en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue12en_US
dc.identifier.pmid25520222en_US
dc.identifier.scopus2-s2.0-84921344966en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage753en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2014_145
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16312
dc.identifier.volume115en_US
dc.identifier.wosWOS:000348244100004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCardiac Veinen_US
dc.subjectCoolingen_US
dc.subjectNitric Oxideen_US
dc.subjectRosuvastatinen_US
dc.titleRole of the nitric oxide on rosuvastatin-induced relaxation of the calf cardiac vein during coolingen_US
dc.typeArticleen_US

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