Yaşa Bağlı Maküla Dejenerasyonun Farklı Alt Tiplerinde Subfoveal Koroid Kalınlığının Değerlendirilmesi
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Tarih
2017
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info:eu-repo/semantics/openAccess
Özet
Amaç: Yaşa bağlı maküla dejenerasyonunun (YBMD) farklı alt tiplerinde subfoveal koroid kalınlığı (SFKK) değişikliklerinin, yaşa bağlı SFKK değişimi ile birlikte değerlendirilmesi. Gereç ve Yöntemler: Çalışmaya YBMD hastalığı olan 90 olgunun 178 gözü (YBMD grubu) ile herhangi bir koryoretinal patolojisi olmayan 102 olgunun 204 gözü (kontrol grubu) dahil edildi. Kontrol grubu üç ardışık yaş grubuna bölündü: A (20-34 yaş), B (35-49 yaş) ve C (50 yaş). Koroid kalınlığı subfoveal alanda SD-OCT cihazının "enhanced depth imaging" programı kullanılarak ölçüldü. Bulgular: Her iki grupta SFKK yaş ile negatif korelasyon gösterdi. Kontrol grubunda SFKK'da her dekadda 25.8 µm azalma tespit edildi. Yaşa göre düzeltme sonrasında SFKK'nın YBMD grubunda hem neovasküler hem de neovasküler olmayan tiplerinde kontrol grubunda 50 yaş olgulara göre azalmış olduğu görüldü (tümü için p0,001). Neovasküler ve neovasküler olmayan YBMD tipleri arasında yaşa göre düzeltilmiş SFKK açısından fark yoktu (p0,710). Neovasküler olmayan YBMD'li gözler içerisinde, coğrafi atrofi mevcut olanlarda SFKK'da daha fazla azalma tespit edildi (p0,001). Neovasküler YBMD'li gözler içerisinde, subfoveal skarlaşma mevcut olanlarda SFKK'da daha fazla azalma tespit edildi (p0,001). YBMD grubunda ileri YBMD bulgusu olan gözlerde SFKK'nın ileri YBMD bulgusu olmayan gözlere göre azalmış olduğu görüldü (p0,006). Sonuç: SFKK yaşla birlikte azalmakta olup, YBMD hastalarında hem neovasküler hem de neovaküler olmayan gruplarda daha fazla azalmaktadır. YBMD hastalığındaki ilerlemenin azalmış koroid kalınlığı ile ilişkili olduğu gö- rülmektedir.
Objectives: To evaluate the alterations in subfoveal choroidal thickness (SFCT) in different subtypes of age related macular degeneration (AMD) in comparison with the age-related change in SFCT. Material and Methods: 178 eyes of 90 patients with AMD (AMD group) and 204 eyes of 102 subjects without any chorioretinal pathologies (control group) were included. Control group was divided into 3 consecutive age groups: A (20-34 years), B (35-49 years) and C ( 50 years). Choroidal thickness was measured at the subfoveal region using the enhanced depth imaging program of a SD-OCT. Results: In both groups, SFCT showed a negative correlation with age. SFCT decreased 25.8 µm for each decade in the control group. After adjustment for age, the mean SFCT in AMD group, both non-neovascular and neovascular forms, were significantly reduced compared with the eyes in control subjects of 50 years of age (p0.001 for all). There was no difference in age-adjusted SFCT between eyes with non-neovascular and neovascular AMD (p0.710). Among the eyes with non-neovascular AMD, those with geographic atrophy had a further reduction in SFCT (p0.001). Among the eyes with neovascular AMD, those with subfoveal scarring had a further reduction in SFCT (p0.001). In the AMD group, SFCT in the eyes with the signs of advanced AMD was significantly reduced compared with the eyes without the signs of advanced AMD (p0.006). Conclusion: SFCT was reduced with increasing age and further reduced in patients with AMD, both in non-neovascular and neovascular forms. Progression of the AMD seems to be related with a further reduction in SFCT.
Objectives: To evaluate the alterations in subfoveal choroidal thickness (SFCT) in different subtypes of age related macular degeneration (AMD) in comparison with the age-related change in SFCT. Material and Methods: 178 eyes of 90 patients with AMD (AMD group) and 204 eyes of 102 subjects without any chorioretinal pathologies (control group) were included. Control group was divided into 3 consecutive age groups: A (20-34 years), B (35-49 years) and C ( 50 years). Choroidal thickness was measured at the subfoveal region using the enhanced depth imaging program of a SD-OCT. Results: In both groups, SFCT showed a negative correlation with age. SFCT decreased 25.8 µm for each decade in the control group. After adjustment for age, the mean SFCT in AMD group, both non-neovascular and neovascular forms, were significantly reduced compared with the eyes in control subjects of 50 years of age (p0.001 for all). There was no difference in age-adjusted SFCT between eyes with non-neovascular and neovascular AMD (p0.710). Among the eyes with non-neovascular AMD, those with geographic atrophy had a further reduction in SFCT (p0.001). Among the eyes with neovascular AMD, those with subfoveal scarring had a further reduction in SFCT (p0.001). In the AMD group, SFCT in the eyes with the signs of advanced AMD was significantly reduced compared with the eyes without the signs of advanced AMD (p0.006). Conclusion: SFCT was reduced with increasing age and further reduced in patients with AMD, both in non-neovascular and neovascular forms. Progression of the AMD seems to be related with a further reduction in SFCT.
Açıklama
Anahtar Kelimeler
Macular degeneration, Choroid, Choroidal neovascularization, Geographic atrophy, Tomography, Optical coherence, Makula dejenerasyonu, Koroid, Koroidal neovaskülarizasyon, Jeografik atrofi, Tomografi, Optik koherens
Kaynak
Türkiye Klinikleri Oftalmoloji Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
26
Sayı
4
Künye
Belviranlı, S., Zengin, N., Doğru, İ., Şatırtav, Günhal., Bitirgen, G. (2017). Yaşa bağlı maküla dejenerasyonun farklı alt tiplerinde subfoveal koroid kalınlığının değerlendirilmesi. Türkiye Klinikleri Oftalmoloji Dergisi, 26, 4, 238-244.
