Celecoxib administration reduced mortality, mesenteric hypoperfusion, aortic dysfunction and multiple organ injury in septic rats

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dc.contributor.authorOzer, Erdem Kamil
dc.contributor.authorGoktas, Mustafa Tugrul
dc.contributor.authorKilinc, Ibrahim
dc.contributor.authorBariskaner, Hulagu
dc.contributor.authorUgurluoglu, Ceyhan
dc.contributor.authorIskit, Alper Bektas
dc.date.accessioned2024-02-23T14:02:14Z
dc.date.available2024-02-23T14:02:14Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractBackground: The cyclooxygenase (COX)-2 overexpression is associated with vascular injury and multiple organ failure in sepsis. However, constitutive COX-1 and basal COX-2 expressions have physiological effects. We aimed to investigate the effects of partial and selective COX-2 inhibition without affecting constitutive COX-1 and basal COX-2 activities by celecoxib on mesenteric artery blood flow (MABF), vascular reactivity, oxidative and inflammatory injuries, and survival in septic rats accomplished by cecal ligation and puncture (CLP). Methods: Wistar rats were allocated into Sham, CLP, Sham + celecoxib, CLP + celecoxib subgroups. 2 h after Sham and CLP operations, celecoxib (0.5 mg/kg) or vehicle (saline; 1 mL/kg) was administered orally to rats. 18 h after drug administrations, MABF and responses of isolated aortic rings to phenylephrine were measured. Tissue samples were obtained for biochemical and histopathological examinations. Furthermore, survival rate was monitored throughout 96 h. Results: Celecoxib ameliorated mesenteric hypoperfusion and partially improved aortic dysfunction induced by CLP. Survival rate was % 0 at 49th h in CLP group, but in CLP + celecoxib group it was 42.8% at the end of 96 h. Serum AST, ALT, LDH, BUN, Cr and inflammatory cytokine (tumor necrosis factor-alpha, interleukin-1 beta and interleukin-6) levels were increased in CLP group that were prevented by celecoxib. The decreases in liver and spleen glutathione levels and the increases in liver, lung, spleen and kidney malondialdehyde levels in CLP group were blocked by celecoxib. The histopathological protective effects of celecoxib on organ injury due to CLP were also observed. Conclusions: Celecoxib has protective effects on sepsis due to its preservative effects on mesenteric perfusion, aortic function and its anti-inflammatory and antioxidative effects. (C) 2016 Elsevier Masson SAS. All rights reserved.en_US
dc.description.sponsorshipSelcuk University Scientific Research Coordination [15401079]en_US
dc.description.sponsorshipSelcuk University Scientific Research Coordination supported this study (No: 15401079).en_US
dc.identifier.doi10.1016/j.biopha.2016.11.102
dc.identifier.endpage589en_US
dc.identifier.issn0753-3322
dc.identifier.issn1950-6007
dc.identifier.pmid28024294en_US
dc.identifier.scopus2-s2.0-85006880740en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage583en_US
dc.identifier.urihttps://doi.org/10.1016/j.biopha.2016.11.102
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11640
dc.identifier.volume86en_US
dc.identifier.wosWOS:000395523800072en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevieren_US
dc.relation.ispartofBiomedicine & Pharmacotherapyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCelecoxiben_US
dc.subjectSepsisen_US
dc.subjectSurvival And Multiple Organ Damageen_US
dc.subjectVascular Hyporeactivityen_US
dc.subjectMesenteric Arterial Blood Flowen_US
dc.titleCelecoxib administration reduced mortality, mesenteric hypoperfusion, aortic dysfunction and multiple organ injury in septic ratsen_US
dc.typeArticleen_US

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