Novel and highly efficient bifunctional calixarene thiourea derivatives as organocatalysts for enantioselective Michael reaction of nitroolefins with diketones
Küçük Resim Yok
Tarih
2018
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
New bifunctional calixarene thiourea organocatalysts were synthesized and applied in catalytic asymmetric Michael addition of acetylacetone to various nitroolefins at room temperature. The corresponding adducts were obtained in good to excellent yields with excellent enantioselectivities (up to 92% ee). The present research demonstrates the advantages of incorporating two stereocontrolling structures into a single catalyst. Notably, it offers a simple and convenient doubly stereocontrolled approach for the catalytic asymmetric synthesis of a chiral organic molecule.
Açıklama
Anahtar Kelimeler
Calixarenes, Asymmetric Michael Addition Reactions, Thiourea, Organocatalysis, Enantioselectivity
Kaynak
Journal Of Inclusion Phenomena And Macrocyclic Chemistry
WoS Q Değeri
Q3
Scopus Q Değeri
Q3
Cilt
90
Sayı
1.Şub
