Novel and highly efficient bifunctional calixarene thiourea derivatives as organocatalysts for enantioselective Michael reaction of nitroolefins with diketones

Küçük Resim Yok

Tarih

2018

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Springer

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

New bifunctional calixarene thiourea organocatalysts were synthesized and applied in catalytic asymmetric Michael addition of acetylacetone to various nitroolefins at room temperature. The corresponding adducts were obtained in good to excellent yields with excellent enantioselectivities (up to 92% ee). The present research demonstrates the advantages of incorporating two stereocontrolling structures into a single catalyst. Notably, it offers a simple and convenient doubly stereocontrolled approach for the catalytic asymmetric synthesis of a chiral organic molecule.

Açıklama

Anahtar Kelimeler

Calixarenes, Asymmetric Michael Addition Reactions, Thiourea, Organocatalysis, Enantioselectivity

Kaynak

Journal Of Inclusion Phenomena And Macrocyclic Chemistry

WoS Q Değeri

Q3

Scopus Q Değeri

Q3

Cilt

90

Sayı

1.Şub

Künye