Chromatographic Multivariate Calibration Approaches to the Simultaneous Quantification of Three Different Drugs in Effervescent Tablets
Küçük Resim Yok
Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Colegio Farmaceuticos Provincia De Buenos Aires
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this research paper, PCR and PLS calibration models were used for processing chromatographic data to get the simultaneous quantification of paracetamol (PAR), caffeine (CAF) and aspirin (ASP) in effervescent tablets. The chromatographic data of the calibration set and samples of analytes were obtained by measuring photodiode array (PDA) detection at a set of eight different wavelengths (245, 250, 255, 260, 265, 270, 275, and 280 nm). Chromatographic analysis was accomplished using an Acquity UPLC BEH Phenyl (50 x 2.1 mm id, 1.7 mu m) column and a mobile phase consisting of 0.1 M acetic acid and methanol (75:25, v/v) with a flow rate of 0.35 mL/min. The validation for the proposed multivariate chromatographic PLS and PCR approaches were accomplished by the analysis of the validation samples containing PAR, CAF, and ASP. Analysis results of chromatographic PLS and PCR techniques were compared to those of traditional ultra-performance liquid chromatography and then comparable results were reported.
Açıklama
Anahtar Kelimeler
Aspirin, Caffeine Ultra-Performance Liquid Chromatography, Paracetamol Partial Least Squares, Principal Component Regression
Kaynak
Latin American Journal Of Pharmacy
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
38
Sayı
6
