Chromatographic Multivariate Calibration Approaches to the Simultaneous Quantification of Three Different Drugs in Effervescent Tablets

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dc.contributor.authorSelimoglu, Faysal
dc.contributor.authorKadioglu, Yucel
dc.contributor.authorDinc, Erdal
dc.date.accessioned2024-02-23T14:49:15Z
dc.date.available2024-02-23T14:49:15Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractIn this research paper, PCR and PLS calibration models were used for processing chromatographic data to get the simultaneous quantification of paracetamol (PAR), caffeine (CAF) and aspirin (ASP) in effervescent tablets. The chromatographic data of the calibration set and samples of analytes were obtained by measuring photodiode array (PDA) detection at a set of eight different wavelengths (245, 250, 255, 260, 265, 270, 275, and 280 nm). Chromatographic analysis was accomplished using an Acquity UPLC BEH Phenyl (50 x 2.1 mm id, 1.7 mu m) column and a mobile phase consisting of 0.1 M acetic acid and methanol (75:25, v/v) with a flow rate of 0.35 mL/min. The validation for the proposed multivariate chromatographic PLS and PCR approaches were accomplished by the analysis of the validation samples containing PAR, CAF, and ASP. Analysis results of chromatographic PLS and PCR techniques were compared to those of traditional ultra-performance liquid chromatography and then comparable results were reported.en_US
dc.description.sponsorshipAnkara University [10A3336001]en_US
dc.description.sponsorshipThis study was performed at the Chemometrics Laboratory of Faculty of Pharmacy, which was supported by the scientific research fund of Ankara University (Project Number 10A3336001). The authors thank Ankara University for their support regarding Chemometrics Laboratory.en_US
dc.identifier.endpage1101en_US
dc.identifier.issn0326-2383
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85067987453en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1091en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/18072
dc.identifier.volume38en_US
dc.identifier.wosWOS:000472899800003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherColegio Farmaceuticos Provincia De Buenos Airesen_US
dc.relation.ispartofLatin American Journal Of Pharmacyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAspirinen_US
dc.subjectCaffeine Ultra-Performance Liquid Chromatographyen_US
dc.subjectParacetamol Partial Least Squaresen_US
dc.subjectPrincipal Component Regressionen_US
dc.titleChromatographic Multivariate Calibration Approaches to the Simultaneous Quantification of Three Different Drugs in Effervescent Tabletsen_US
dc.typeArticleen_US

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