Koroner Kalp Hastalarında Asimetrik Dimetil Arjinin Düzeyleri Ve Dimetilarjinin Dimetilamino Hidrolaz Enziminin Genetic Polimorfizmi

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dc.contributor.authorAbuşoğlu, Sedat
dc.contributor.authorÜnlü, Ali
dc.contributor.authorÇelik, Hüseyin Tuğrul
dc.contributor.authorTaner, Alpaslan
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorÖç, Mehmet Alkılıç Horasanı
dc.date.accessioned2020-01-18T21:03:21Z
dc.date.available2020-01-18T21:03:21Z
dc.date.issued2014
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Anabilim Dalıen_US
dc.description.abstractKoroner kalp hastalığı olan bireylerde genetik olarak polimorfizm olması kardiyovasküler olaylara yatkınlığı arttırabilir. Dimetilarjinin Dimetilamino Hidrolaz (DDAH) enziminde bu genetik değişimin saptanması ile bu hastalık grubunda daha ileri tedavi protokolleri geliştirilmesine katkı sağlamak için koroner kalp hastalarında Asimetrik Dimetil Arjinin (ADMA) seviyeleri ve DDAH 1 (E.C. 3.5.3.18) enziminin T87M mutasyonu incelendi.en_US
dc.description.abstractBackground: Genetic polymorphism may enhance the predisposition to cardiovascular events in patients with coronary heart disease (CHD). The aim of this study is to contribute further treatment protocol development via investigation serum ADMA levels and dimethylarginine dimethylaminohydrolase DDAH 1 (E.C. 3.5.3.18) T87M mutation of CHD patients. Material and Methods: 50 CHD patients and 50 healthy volunteers from Konya region were included to this study. Serum ADMA levels were analyzed by high performance liquid chromatograpy. DDAH (E.C. 3.5.3.18) T87M mutation were determined by PCR from extracted whole blood DNA samples. Results: ADMA levels were significantly higher in patient group compared to control group and there was no statistically diffference between groups for Arginine / ADMA ratio (p>0.001, p0.08 respectively). Triglyceride levels were significantly higher in patient group compared to control group (p0.033) and HDL- cholesterol levels were significantly lower in patient group compared to control group (p>0.001). In DDAH 1 T87M polymorphism gene analysis, there was only one heterozygote patient, the other participiants were wildtype. Conclusions: Polymorphism studies with wider population and detailed investigation of risk factors in these polymorphic subjects will contribute to ensure the role of high ADMA levels in cardiovascular diseases.en_US
dc.identifier.citationAbuşoğlu, S., Ünlü, A., Çelik, H. T., Taner, A., Kayrak, M., Öç, M. A. H. (2014). Koroner kalp hastalarında asimetrik dimetil arjinin düzeyleri ve dimetilarjinin dimetilamino hidrolaz enziminin genetic polimorfizmi. Yeni Tıp Dergisi, 31, 3, 192-197.en_US
dc.identifier.endpage197en_US
dc.identifier.issn1300-2317en_US
dc.identifier.issue3en_US
dc.identifier.startpage192en_US
dc.identifier.urihttp://app.trdizin.gov.tr/publication/paper/detail/TVRZMU5UVXdNQT09
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1544
dc.identifier.volume31en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isotren_US
dc.relation.ispartofYeni Tıp Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGenel ve Dahili Tıpen_US
dc.subjectKoroner Kalp Hastalığıen_US
dc.subjectDimetilarjinin Dimetilamino Hidrolazen_US
dc.subjectGenetik Polimorfizmen_US
dc.subjectRisk Değerlendirmesien_US
dc.subjectCoronary Heart Diseaseen_US
dc.subjectDimethylarginine Dimethylaminohydrolaseen_US
dc.subjectGenetic Polymorphismen_US
dc.subjectRisk Assesmenten_US
dc.titleKoroner Kalp Hastalarında Asimetrik Dimetil Arjinin Düzeyleri Ve Dimetilarjinin Dimetilamino Hidrolaz Enziminin Genetic Polimorfizmien_US
dc.title.alternativeInvestigation of the (DDAH1) T87M mutation of dimethylarginine dimethylaminohydrolase (DDAH E.C. 3.5.3.18) (DDAH 1) enzyme and the levels of asymmetric dimethylarginine (ADMA) in patients with coronary heart diseaseen_US
dc.typeArticleen_US

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