Primer anorektal malign melanom: 5 Yıllık tek merkez deneyimi
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Dosyalar
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Gastrointestinal sistemde Malign Melanom beklenmedik bir durumdur fakat nadir değildir. Primer Malign melanom anorektol bölgede nadir görülür. Uzun dönem yaşam beklentisi nadirdir. Çoğu hasta tedavi edilemeyen sistemik hastalık nedeniyle kaybedilmektedir. Bu çalışmada Malign Melanomla ilgili klinik deneyimlerimizi aktararak, tanı ve tedavisi ile ilgili güncel literatür bilgilerini paylaşmayı amaçladık. Materyal ve metot: 2006-2011 tarihleri arasında cerrahi girişimde bulunulan ve patolojik tanısı Malign Melanom olan 10 olgu retrospektif olarak incelendi. Hastalar yaş, cinsiyet, klin görünüm, metastaz varlığı, immünhistokimyasal özelliği, takip süreleri ve uygulanan cerrahi girişimin açısından değerlendirildi. Bulgular: Hastaların 4'ü kadın, 6'si erkek olup yaş ortalaması 67,7 (50-83)' idi. Beş hastada cerrahi tedavi ile kür sağlandı. Dört hasta inoperable olarak tespit edildi. Tüm vakalarda S-100 pozitifti. Hastalar ortalama 15 (5-24) ay takip edildi. Sonuçlar: Primer anorektal malign melanom, anorektal tümörlerin ayırıcı tanısında nadir bir nedendir. Tercih edilen tedavi seçeneği cerrahidir. Palyatif amaçlı kemoterapi ve immünoterapi kullanılır. Tedavi yöntemlerindeki gelişmelere rağmen, bu tümörün prognozu halen kötüdür.
Background: Malignant melanoma in the gastrointestinal tract is uncommon but not rare. Primary malignant melanoma is a rare entity in the anorectum. Longterm survival is rare, as most patients die of disseminated systemic disease regardless of treatment. In this study we are aiming to share the most up to date knowledge about diagnosis and treatment of these tumors by transferring our clinical experience about malignant melanoma. Methods: The 10 patients who was operated and pathologic examination were reported as malignant melanoma between 20062011 years have been viewed retrospectively. Patients' age, sex, clinical, presence of metastasis, survival and immunohistopathologic features and treatment methods were evaluated. Results: Four of patients were women and 6 of them were men whose age averages were 67,7 (50-83). With a surgical intervention 5 of them had been cured. 4 cases accepted as an inoperable. S-100 was positive in our all cases. Patients had been observed for 15 (5-24) months. Conclusions: Primary anorectal malignant melanoma is a rare cause in the differential diagnosis of anorectal tumors. Surgery remains the therapy of choice. Chemotherapy and immunotherapy are principally used in a palliative setting. Despite advances in therapy, the prognosis of this tumor entity remains unfavorable.
Background: Malignant melanoma in the gastrointestinal tract is uncommon but not rare. Primary malignant melanoma is a rare entity in the anorectum. Longterm survival is rare, as most patients die of disseminated systemic disease regardless of treatment. In this study we are aiming to share the most up to date knowledge about diagnosis and treatment of these tumors by transferring our clinical experience about malignant melanoma. Methods: The 10 patients who was operated and pathologic examination were reported as malignant melanoma between 20062011 years have been viewed retrospectively. Patients' age, sex, clinical, presence of metastasis, survival and immunohistopathologic features and treatment methods were evaluated. Results: Four of patients were women and 6 of them were men whose age averages were 67,7 (50-83). With a surgical intervention 5 of them had been cured. 4 cases accepted as an inoperable. S-100 was positive in our all cases. Patients had been observed for 15 (5-24) months. Conclusions: Primary anorectal malignant melanoma is a rare cause in the differential diagnosis of anorectal tumors. Surgery remains the therapy of choice. Chemotherapy and immunotherapy are principally used in a palliative setting. Despite advances in therapy, the prognosis of this tumor entity remains unfavorable.
Açıklama
Anahtar Kelimeler
Cerrahi, Habis Melanom, Tümörler, Rektal, Anal Kanal, Tedavi, Malignant Melanoma, Neoplasms, Rectal, Anal Canal, Treatment
Kaynak
Harran Üniversitesi Tıp Fakültesi Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
10
Sayı
1
Künye
Çakır, M., Küçükkartallar,T., Tekin, A., Belviranlı, M., (2013). Primer Anorektal Malign Melanom: 5 Yıllık Tek Merkez Deneyimi Türkçe. Harran Üniversitesi Tıp Fakültesi Dergisi, 1, 10, 11-16.
