Preventing oxygen free radical damage by proanthocyanidin in obstructive jaundice

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dc.authoridMurat Çakır: 0000-0001-8789-8199
dc.authoridAhmet Tekin: 0000-0002-8179-4994
dc.authoridTevfik Küçükkartallar: 0000-0002-6326-4623
dc.authoridHüsamettin Vatansev: 0000-0002-0230-3414
dc.contributor.authorSavdan, Mervan
dc.contributor.authorÇakır, Murat
dc.contributor.authorVatansev, Hüsamettin
dc.contributor.authorKüçükkartallar, Tevfik
dc.contributor.authorTekin, Ahmet
dc.contributor.authorTavlı, Şakir
dc.date.accessioned2020-01-18T21:12:16Z
dc.date.available2020-01-18T21:12:16Z
dc.date.issued2017
dc.departmentNEÜ, Meram Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Anabilim Dalıen_US
dc.description.abstractObjective: Tissue damage and endotoxemia in obstructive jaundice are attributed to the increase in oxygen freeradicals. We aimed at evaluating the possible protective effect of grape seed proanthocyanidin extract (GSPE), whichis a potent exogenous free-radical scavenger and antioxidant.Material and Methods: The study was performed at the Necmettin Erbakan University Meram School of MedicineResearch and Application Center for Experimental Medicine Laboratory with ethical approval. 30 Wistar-Albino ratswere used and were divided into 3 groups. The common bile duct was identified and only dissected in the first group(sham). Following dissection of the common bile duct it was ligated with 4/0 silk just above the pancreas in thesecond group (control). After ligation of the common bile duct, 100mg/kg/day GSPE was administered via orogastriclavage for 10 days in the third group.Results: Biochemical values revealed a statistically significant difference between Group I and the others. There wasno difference between Group II and III regarding biochemical values. There was a statistically significant difference,however, between Group II and III with regards to nitric oxide levels. There was a statistically significant differencebetween Group I and the other groups concerning hepatic and pulmonary tissue damage on histopathologic evaluation. There was no difference among the groups with regards to renal tubular damage.Conclusion: Proanthocyanidin is an effective natural antioxidant in decreasing the level of tissue damage causedby oxygen free-radicals.en_US
dc.identifier.citationSavdan, M., Çakır, M., Küçükkartallar, T., Tekin, A., Tavlı, Ş., Vatansev, H. (2017). Preventing oxygen free radical damage by proanthocyanidin in obstructive jaundice. Turkish Journal of Surgery, 33, 2, 62-68.en_US
dc.identifier.doi10.5152/turkjsurg.2017.3337en_US
dc.identifier.endpage68en_US
dc.identifier.issn2564-6850en_US
dc.identifier.issn2564-7032en_US
dc.identifier.issue2en_US
dc.identifier.startpage62en_US
dc.identifier.urihttps://dx.doi.org/10.5152/turkjsurg.2017.3337
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWpJM05UazVPUT09/preventing-oxygen-free-radical-damage-by-proanthocyanidin-in-obstructive-jaundice
dc.identifier.urihttps://hdl.handle.net/20.500.12452/2739
dc.identifier.volume33en_US
dc.identifier.wosWOS:000403585500005en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Surgeryen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidanten_US
dc.subjectJaundiceen_US
dc.subjectProanthocyanidinen_US
dc.titlePreventing oxygen free radical damage by proanthocyanidin in obstructive jaundiceen_US
dc.typeArticleen_US

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