Can the Ratio of Calcium to Albumin Predict the Severity of Aortic Stenosis?

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dc.contributor.authorAlsancak, Yakup
dc.contributor.authorSivri, Serkan
dc.contributor.authorBastug, Serdal
dc.contributor.authorAyhan, Huseyin
dc.contributor.authorBozkurt, Engin
dc.date.accessioned2024-02-23T14:41:06Z
dc.date.available2024-02-23T14:41:06Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractObjective: Aortic sclerosis is observed in 25% of the elderly population, and 2.5% of these patients have severe aortic stenosis (AS). Numerous studies have reported a relationship between the serum calcium or albumin levels and AS. The present study investigated the relationship between the calcium toalbumin ratio (CAR) and AS. Methods: Our study included 185 patients and 108 subjects as the control group. A routine transthoracic echocardiographic evaluation and laboratory examinations were performed inall participants. The corrected serum calcium levels were calculated using the most commonly used formula: corrected calcium=measured total calcium (mg/dL) + 0.8 (4.0-serum albumin [g/dL]). Results: The serum C-reactive protein CRP, calcium, and corrected calcium levels were significantly different between the study groups (p<0.05), and the albumin levels were significantly decreased parallel with the AS severity (p<0.001). Also, we detected a negative correlation between the albumin and corrected calcium levels and the EuroSCORE. CAR and corrected calcium to albumin ratio (cCAR) were significantly higher in the AS group, as expected (p<0.01). In the logistic regression analysis, albumin, CRP, low-density lipoprotein LDL, theCAR, and cCAR levels were found to be significantly and independently associated with the presence of AS (p<0.05). Moreover, in a regression analysis in the subgroup of AS only, albumin, the cCAR, and CAR were independently associated with the presence of very severe AS. Conclusion: Our study showed an important relationship between the CAR and AS. Therefore, in clinical practice, this simple, inexpensive, and practical method may predict the severity of AS.en_US
dc.identifier.doi10.5152/EurJTher.2018.761
dc.identifier.endpage50en_US
dc.identifier.issn2564-7784
dc.identifier.issn2564-7040
dc.identifier.issue1en_US
dc.identifier.startpage44en_US
dc.identifier.urihttps://doi.org/10.5152/EurJTher.2018.761
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16708
dc.identifier.volume25en_US
dc.identifier.wosWOS:000462160300008en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofEuropean Journal Of Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlbuminen_US
dc.subjectAortic Stenosisen_US
dc.subjectCalciumen_US
dc.subjectCalcium To Albumin Ratioen_US
dc.titleCan the Ratio of Calcium to Albumin Predict the Severity of Aortic Stenosis?en_US
dc.typeArticleen_US

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