Sistemik Lupus Eritematozus’lu Hastalarda Subklinik Ateroskleroz ve Sindekan-4 Düzeyinin İlişkisinin Değerlendirilmesi
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Tarih
2023
Yazarlar
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Yayıncı
Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Sistemik Lupus Eritematozus (SLE), kronik inflamatuvar otoimmun bir hastalıktır. SLE hastalarında oluştuğu bilinen subklinik ateroskleroz süreci ile hastalık aktivitesini karşılaştırmak için karotis intima media kalınlığı (CIMT), hastalık aktivite indeksi (SLEDAI) ve sindekan 4 düzeyleri ile ilişkisini sağlıklı gönüllüler ile kıyaslayarak incelemeye çalıştık.
Materyal ve Metod: Romatoloji polikliniğine başvuran 18 yaş üstü, bilinen başka sistemik hastalığı olmayan 65 SLE hastası ve sağlıklı 65 gönüllü çalışmaya dâhil edildi. ELISA yöntemiyle sindekan-4 düzeyleri çalışıldı. Hasta ve kontrol grubunun karotis intima media kalınlıkları ölçüldü. Hastaların SLE hastalık aktivite indeksi (SLEDAI), hasta ve kontrol grubunun sosyodemografik ve laboratuvar verileri istastistik programına (SPSS) kaydedilerek veriler analiz edildi.
Bulgular: Hasta grubunun sindekan-4 (SDC4) değeri (8.211±9.069) ile kontrol gurubunun sindekan-4 değeri (26.221±24.653) (p=0.000)’ne kıyasla istatistiksel olarak anlamlı derecede düşük bulundu.. Hasta grubunun CIMT değeri (0.558±0.116) ile kontrol gurubunun CIMT değeri (0.49±0.117) (p=0.001), arasında istatistiksel olarak anlamlı bir farklılık vardı. SDC4 ve CIMT arasında anlamlı bir korelasyon saptandı (p<0.05). Sindekan 4 düzeyi ile beden kitle indeksi (BMI) arasında anlamlı bir korelasyon saptandı (p<0.05). Hasta grubunun SDC4 düzeyleri ile hastalık aktivite indeksi (SLEDAI) arasında anlamlı bir korelasyon saptandı (p<0.05). Yine hasta grubunda CIMT ve SLEDAİ arasında anlamlı bir korelasyon saptandı (p<0.05).
Sonuç: Subklinik aterosklerozun önemli bir göstergesi olan karotis intima media kalınlığının bizim hasta grubumuzda kontrol grubuna göre anlamlı derecede yüksek olmasına rağmen, Sindekan-4 düzeylerinin aterosklerozu öngörmede güvenilir olmadığını düşünmekteyiz.
Objective: Systemic Lupus Erythematosus (SLE) is a chronic inflammatory autoimmune disease. In order to compare the subclinical atherosclerosis process known to occur in SLE patients with disease activity, we tried to examine the relationship between carotid intima media thickness (CIMT), disease activity index (SLEDAI) and syndecan 4 levels by comparing them with healthy volunteers. Materials and Methods: 65 SLE patients over 18 years of age, without any other known systemic health system, and 65 healthy volunteers were included in the rheumatology outpatient clinic. Syndecan-4 aspect was studied by ELISA method. Carotid intima media thicknesses of the patient and control groups were measured. The patients' SLE disease activity index (SLEDAI), sociodemographic and laboratory data of the patient and control groups were analyzed by recording statistical data (SPSS). Results: The syndecan-4 (SDC4) value of the patient group (8.211±9.069) and the syndecan-4 value of the control group (26.221±24.653) (p=0.000) were found to be statistically significantly lower. The CIMT value of the patient group (0.558±0.116) and the control group were found to be significantly lower. There was a statistically significant difference between the CIMT value (0.49±0.117) (p=0.001) of the group. A significant correlation was found between SDC4 and CIMT (p<0.05). A significant correlation was found between SDC4 level and body mass index (BMI) (p<0.05). A significant correlation was found between SDC4 levels and disease activity index (SLEDAI) of the patient group (p<0.05). Again, a significant correlation was found between CIMT and SLEDAI in the patient group (p<0.05). Conclusion: Although the carotid intima media depth, which is an important indicator of subclinical atherosclerosis, was generally higher in our patient group compared to our control group, we think that the Syndecan-4 levels is not reliable in detecting atherosclerosis
Objective: Systemic Lupus Erythematosus (SLE) is a chronic inflammatory autoimmune disease. In order to compare the subclinical atherosclerosis process known to occur in SLE patients with disease activity, we tried to examine the relationship between carotid intima media thickness (CIMT), disease activity index (SLEDAI) and syndecan 4 levels by comparing them with healthy volunteers. Materials and Methods: 65 SLE patients over 18 years of age, without any other known systemic health system, and 65 healthy volunteers were included in the rheumatology outpatient clinic. Syndecan-4 aspect was studied by ELISA method. Carotid intima media thicknesses of the patient and control groups were measured. The patients' SLE disease activity index (SLEDAI), sociodemographic and laboratory data of the patient and control groups were analyzed by recording statistical data (SPSS). Results: The syndecan-4 (SDC4) value of the patient group (8.211±9.069) and the syndecan-4 value of the control group (26.221±24.653) (p=0.000) were found to be statistically significantly lower. The CIMT value of the patient group (0.558±0.116) and the control group were found to be significantly lower. There was a statistically significant difference between the CIMT value (0.49±0.117) (p=0.001) of the group. A significant correlation was found between SDC4 and CIMT (p<0.05). A significant correlation was found between SDC4 level and body mass index (BMI) (p<0.05). A significant correlation was found between SDC4 levels and disease activity index (SLEDAI) of the patient group (p<0.05). Again, a significant correlation was found between CIMT and SLEDAI in the patient group (p<0.05). Conclusion: Although the carotid intima media depth, which is an important indicator of subclinical atherosclerosis, was generally higher in our patient group compared to our control group, we think that the Syndecan-4 levels is not reliable in detecting atherosclerosis
Açıklama
Anahtar Kelimeler
Ateroskleroz, BMI, CIMT, Sindekan-4, SLE, SLEDAI, Atherosclerosis, BMI, CIMT, Sindecan-4, SLE, SLEDAI
Kaynak
WoS Q Değeri
Scopus Q Değeri
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Künye
Yümer, A. (2023). Sistemik Lupus Eritematozus’lu Hastalarda Subklinik Ateroskleroz ve Sindekan-4 Düzeyinin İlişkisinin Değerlendirilmesi. (Yayınlanmamış tıpta uzmanlık tezi) Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi Dahili Tıp Bilimleri Bölümü İç Hastalıkları Anabilim Dalı, Konya.
