Akut apandisitte Ca125, CA19.9 ve karsinoembriyonik antijenden oluşan tümör belirteçlerinin rolü
Yükleniyor...
Dosyalar
Tarih
2015
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Bu çalışmada, CA125, CA19.9 ve karsinoembriyonik antijen (CEA) gibi tümor belirteçlerinin serum değerlerinin akut apandisit (AA) tanısında herhangi bir değerinin olup olmadığı araştırıldı. Gereç ve yöntem: Akut apandisit tanısı ile ameliyat edilmiş 74 hasta ile 30 sağlıklı kişi bu çalışmaya dahil edildi. Histopatolojik inceleme sonrasında hastalar: akut fokal apandisit (AFA), süpüratif, flegmenöz ve gangrenöz apandisiti içeren ilerlemiş akut apandisit (AİA) ve akut perfore apandisit (APA) olarak sınıflandırıldı. Tümör belirteçleri için kan örnekleri ameliyat öncesi dönemde alındı. Bulgular: Hastaların ve kontrol grubunun CA125, CA19.9 ve CEA düzeyleri sırasıyla 13,349,26 ve 13,338,73; 20,1529,63 ve 12,7517,6; 1,330.97 and 1,120,57 idi. Aradaki fark istatistiksel olarak anlamlı değildi. CEA düzeyleri hem hastalarda hem de kontrol grubunda normal sınırlar içerisindeydi. Serum Ca125 düzeyi; 74 hastanın 3'ünde, 30 sağlıklı kişinin 1'inde; serum CA19.9 düzeyi ise hastaların 15'inde, sağlıklı kişilerin 2'sinde yüksekti. Ancak bu aradaki farklar istatistiksel olarak anlamlı değildi. CA125, CA19.9 ve CEA düzeyleri lökosit sayısı, nötrofil oranı, semptomların süresi ve patolojik alt gruplara göre değerlendirildiğinde ise CA 19.9 seviyesi semptom süresi 24 saat olan hastalarda; 24 saat olanlara göre ve histopatolojik olarak AFA tanısı alanlarda APA tanısı alanlara göre daha yüksek bulundu. Sonuç: AFA ve semptom süresi 24 saat olan hastalarda serum CA 19.9 düzeyleri yüksek olmasına karşın, AA tanısında hala hikaye ve fizik muayenenin ana tanı yöntemi olduğu kanısına vardık
The aim of this study is to clarify if the tumor markers including CA125, CA 19.9 and carcinoembriyonic antigen (CEA) concentrations have any role in the diagnosis of acute appendicitis (AA). Material and methods: 74 patients with diagnosis of AA and 30 healthy persons were enrolled in this study. The patients were categorized as acute focal appendicitis (AFA), acute advanced appendicitis (AİA) including acute supurative, phlegmonous and gangrenous appendicitis, and acute perforated appendicitis (APA) according to the results of histopathological examination. Serum samples were obtained during preoperative period. Results: The CA125; CA19.9; and CEA levels of the patients and control group were 13.34±9.26 and 13.33±8.73; 20.15±29.63 and 12.75±17.6; 1.33±0.97 and 1.12±0.57, respectively. These differences between the levels of tumor markers in study and control groups were not significant statistically. CEA levels were in normal limits in both the patients' and control group. Although serum CA125 levels were high in 3 of 74 patients and 1 of 30 healthy persons and serum CA19.9 levels were high in 15 of the patients and 2 of the healthy per- sons, these differences were not significant. When serum CEA, CA125 and CA19-9 levels of patients were analyzed according to leu- kocyte count, neutrophil rates, duration of symptoms, and pathologic subgroup; the serum CA19.9 levels of the patients with duration of symptoms > 24 hours were higher than the patients with the duration of the symptoms < 24 hours (p0.04), and the serum CA 19.9 levels of the patients with diagnosis of APA were lower than AFA (p0.02). Conclusion: We concluded that the history and physical examination of the patient are still the main diagnostic tool in diagnosis of the AA, although high CA 19.9 levels in the patients with AFA and having the duration of symptoms > 24 hours
The aim of this study is to clarify if the tumor markers including CA125, CA 19.9 and carcinoembriyonic antigen (CEA) concentrations have any role in the diagnosis of acute appendicitis (AA). Material and methods: 74 patients with diagnosis of AA and 30 healthy persons were enrolled in this study. The patients were categorized as acute focal appendicitis (AFA), acute advanced appendicitis (AİA) including acute supurative, phlegmonous and gangrenous appendicitis, and acute perforated appendicitis (APA) according to the results of histopathological examination. Serum samples were obtained during preoperative period. Results: The CA125; CA19.9; and CEA levels of the patients and control group were 13.34±9.26 and 13.33±8.73; 20.15±29.63 and 12.75±17.6; 1.33±0.97 and 1.12±0.57, respectively. These differences between the levels of tumor markers in study and control groups were not significant statistically. CEA levels were in normal limits in both the patients' and control group. Although serum CA125 levels were high in 3 of 74 patients and 1 of 30 healthy persons and serum CA19.9 levels were high in 15 of the patients and 2 of the healthy per- sons, these differences were not significant. When serum CEA, CA125 and CA19-9 levels of patients were analyzed according to leu- kocyte count, neutrophil rates, duration of symptoms, and pathologic subgroup; the serum CA19.9 levels of the patients with duration of symptoms > 24 hours were higher than the patients with the duration of the symptoms < 24 hours (p0.04), and the serum CA 19.9 levels of the patients with diagnosis of APA were lower than AFA (p0.02). Conclusion: We concluded that the history and physical examination of the patient are still the main diagnostic tool in diagnosis of the AA, although high CA 19.9 levels in the patients with AFA and having the duration of symptoms > 24 hours
Açıklama
Anahtar Kelimeler
Genel ve Dahili Tıp, Akut Apandisit, CA 125, CA 19.9, CEA, Acute Appendicitis
Kaynak
Genel Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
25
Sayı
3
Künye
Köksal, H. (2015). Akut apandisitte Ca125, CA19.9 ve karsinoembriyonik antijenden oluşan tümör belirteçlerinin rolü. Genel Tip Dergisi, 25, 3, 81-84.
