The effects of botulinum toxin A and papaverine on human saphenous vein and internal mammary artery grafts: an in vitro study

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dc.contributor.authorDuman, Ipek
dc.contributor.authorTanyeli, Omer
dc.contributor.authorDereli, Yuksel
dc.contributor.authorOltulu, Pembe
dc.contributor.authorToy, Hatice
dc.contributor.authorSahin, Ayse Saide
dc.date.accessioned2024-02-23T14:40:54Z
dc.date.available2024-02-23T14:40:54Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractIntroduction: Autologous saphenous vein (SV) and internal mammary ar-tery (IMA) are used as bypass conduits during coronary artery bypass graft surgery. Vasospasm of the arterial and venous grafts may constitute a sig-nificant clinical problem. Pretreatment with a vasodilator drug of the graft ex vivo or intraluminal injection before implantation may be used for spasm prophylaxis. This in vitro study was designed to assess the vasoactive ef-fects and time-dependent changes of botulinum toxin A (BTX-A) and pa-paverine pretreatment on vasospasm of human SV and IMA grafts. Also, histomorphology of the vessels was assessed.Material and methods: SV and IMA segments were suspended in organ baths, and isometric contraction responses to 2 different concentrations of 5-hydroxytryptamine (5-HT) and endothelin-1 (ET-1) were recorded after in-cubation with 2 different concentrations of BTX-A and papaverine at 2 time points (0 h and 2 h).Results: The results revealed the following: 1) incubation with BTX-A and papaverine relaxes both SV and IMA rings contracted with 5-HT and ET-1; 2) the duration of the relaxant effect of BTX-A lasts longer than papaverine; and 3) no apparent histomorphological changes were observed in the grafts under light microscopy.Conclusions: This study demonstrates that in human SV and IMA grafts, pretreatment with both BTX-A and papaverine are safe and have a potent inhibitory effect depending on the vessel and vasoconstrictor agent. The long-lasting vasodilatory effect of BTX-A on vascular smooth muscle may provide promising results in the prevention of venous and arterial graft spasm.en_US
dc.description.sponsorshipNecmettin Erbakan University, Scientific Research Projects (BAP) Coordinator [161218008]en_US
dc.description.sponsorshipThe study was approved and supported by the Necmettin Erbakan University, Scientific Research Projects (BAP) Coordinator. Grant Number: 161218008.en_US
dc.identifier.doi10.5114/aoms/110157
dc.identifier.endpage1616en_US
dc.identifier.issn1734-1922
dc.identifier.issn1896-9151
dc.identifier.issue6en_US
dc.identifier.pmid36457963en_US
dc.identifier.scopus2-s2.0-85142924815en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1607en_US
dc.identifier.urihttps://doi.org/10.5114/aoms/110157
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16639
dc.identifier.volume18en_US
dc.identifier.wosWOS:000892482200020en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTermedia Publishing House Ltden_US
dc.relation.ispartofArchives Of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIn Vitroen_US
dc.subjectPapaverineen_US
dc.subjectBotulinum Toxin Aen_US
dc.subjectSaphenous Veinen_US
dc.subjectHuman Internal Mammary Arteryen_US
dc.titleThe effects of botulinum toxin A and papaverine on human saphenous vein and internal mammary artery grafts: an in vitro studyen_US
dc.typeArticleen_US

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