Potential role of interleukin-18 in patients with rheumatoid arthritis-associated carotid intima-media thickness but not insulin resistance

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dc.authoridŞevket Ercan Tunç: 0000-0002-1221-0131
dc.contributor.authorŞahin, Mehmet
dc.contributor.authorUgan, Yunus
dc.contributor.authorTunç, Şevket Ercan
dc.contributor.authorAkın, Şule
dc.contributor.authorKöroğlu, Banu
dc.contributor.authorKutlucan, Ali
dc.contributor.authorSütçü, Recep
dc.contributor.authorYeşildağ, Ahmet
dc.contributor.authorKılbaş, Aysun
dc.date.accessioned2020-01-18T21:02:57Z
dc.date.available2020-01-18T21:02:57Z
dc.date.issued2014
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Radyoloji Anabilim Dalıen_US
dc.description.abstractObjective: Plasma interleukin-18 (IL-18) has been reported to be associated with homeostasis model assessment of insulin resistance (HOMAIR). It also has been described as one of the factors that, in addition to insulin resistance, may also contribute to atherosclerosis. Parameters of systemic inflammation are also significantly associated with circulating IL-18. Our objective was to investigate whether IL-18 is associated with insulin resistance and atherosclerosis in patients with rheumatoid arthritis (RA) in which accelerated atherogenesis develops.Material and Methods: Fifty-one female RA patients and 30 female controls were enrolled in the study; 31 of them were without diseasemodifying antirheumatic drug (DMARD) treatment and had a relatively short disease duration. Disease activity was assessed by Disease Activity Score (DAS) 28 index. HOMA-IR method was used to detect insulin resistance. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), fasting plasma glucose (FPG), insulin, tumor necrosis factor alpha (TNF-?), and IL-18 levels were evaluated. Also, carotid intima-media thickness (cIMT) was measured.Results: There were no differences between patients and the control group according to age, sex, and body mass index. ESR, CRP, insulin, FPG, HOMA-IR, TNF-?, IL-18 levels, and cIMT measurements were significantly high in the patient group. HOMA-IR and cIMT measurements were similar and high in both the DMARD and non-DMARD patient groups. HOMA-IR correlated with TNF-? (r0.308, p0.028), but no correlation was found between IL-18 and HOMA-IR. However, IL-18 was correlated positively with cIMT (r 0.318, p0.028) and negatively with BMI (r-0.360, p0.01).Conclusion: IL-18 is associated with atherosclerosis in RA patients. However, no significant relation was found with insulin resistance. IL-18 may be a marker for early evaluation of atherosclerosis in RA patientsen_US
dc.identifier.citationŞahin, M., Ugan, Y., Tunç, Ş. E., Akın, Ş., Köroğlu, B., Kutlucan, A., Sütçü, R., Yeşildağ, A., Kılbaş, A. (2014). Potential role of interleukin-18 in patients with rheumatoid arthritis-associated carotid intima-media thickness but not insulin resistance. European Journal of Rheumatology, 1, 4, 135-139.
dc.identifier.doi10.5152/eurjrheumatol.2014.140046en_US
dc.identifier.endpage139en_US
dc.identifier.issn2147-9720en_US
dc.identifier.issn2148-4279en_US
dc.identifier.issue4en_US
dc.identifier.startpage135en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWpJek5qZ3dNQT09/potential-role-of-interleukin-18-in-patients-with-rheumatoid-arthritis-associated-carotid-intima-media-thickness-but-not-insulin-resistance
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1383
dc.identifier.volume1en_US
dc.identifier.wosWOS:000218668500002en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.relation.ispartofEuropean Journal of Rheumatologyen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAtherosclerosisen_US
dc.subjectInsulin resistanceen_US
dc.subjectInterleukin-18en_US
dc.subjectRheumatoid arthritisen_US
dc.subjectTumor necrosis factor alphaen_US
dc.titlePotential role of interleukin-18 in patients with rheumatoid arthritis-associated carotid intima-media thickness but not insulin resistanceen_US
dc.typeArticleen_US

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