Alpha-glutathione-s-transferase can be a biomarker for both drug-related toxicity as well as individual susceptibility
Küçük Resim Yok
Tarih
2016
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Edizioni Minerva Medica
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
BACKGROUND: Psychiatric disorders are health concern. The important issue is that the response of treatment of patients is different. Some patients are in remission, some suffer from adverse drug reactions (ADRs). Hepatic function is monitored by liver enzymes. It is important to detect liver injury and its evaluation according to the genetic polymorphisms in early phase of treatment. Alpha-glutathione-s-transfcrase (alpha-CiST) is a sensitive biomarker compared to the liver enzymes. GSTs are phase II conjugation enzymes that detoxify xenobiotic and protect cells from the oxidative stress. GSTMI, GSTT1 and GSTPI are polymorphic. Null genotypes cause lack of activity. Our aim was to investigate whether alpha-GST might be earlier biomarker than liver enzymes for liver injury and impact of individual susceptibility. METHODS: Blood samples before treatment, 10=3 days and 31 months of treatments were taken from 132 psychotic disorder patients in treatment. Serum alpha-GST was measured by Enzyme Linked Immunosorbent Assay (ELISA) and GSTs gene polymorphisms were genotyped, by Pcilymerase Chain Reaction. RESULTS: Our data indicated that alpha-GST might be a btomarket lbr liver injury and GSTs gene polymorphisms had a contribution to the risk of psychotic disorders. CONCLUSIONS: Our results encourage making research on finding more specific biomarker and individual susceptibility with larger sample size.
Açıklama
Anahtar Kelimeler
Antipsychotie Agents, Psychotic Disorders, Glutathione S-Transferase Alpha, Polymorphism, Genetic, Polymerase Chain Reaction
Kaynak
Minerva Psichiatrica
WoS Q Değeri
Scopus Q Değeri
Cilt
57
Sayı
2
