Alpha-glutathione-s-transferase can be a biomarker for both drug-related toxicity as well as individual susceptibility

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dc.contributor.authorCiba, Melda
dc.contributor.authorMehmet, A. K.
dc.contributor.authorKarahalil, Bensu
dc.date.accessioned2024-02-23T14:48:54Z
dc.date.available2024-02-23T14:48:54Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractBACKGROUND: Psychiatric disorders are health concern. The important issue is that the response of treatment of patients is different. Some patients are in remission, some suffer from adverse drug reactions (ADRs). Hepatic function is monitored by liver enzymes. It is important to detect liver injury and its evaluation according to the genetic polymorphisms in early phase of treatment. Alpha-glutathione-s-transfcrase (alpha-CiST) is a sensitive biomarker compared to the liver enzymes. GSTs are phase II conjugation enzymes that detoxify xenobiotic and protect cells from the oxidative stress. GSTMI, GSTT1 and GSTPI are polymorphic. Null genotypes cause lack of activity. Our aim was to investigate whether alpha-GST might be earlier biomarker than liver enzymes for liver injury and impact of individual susceptibility. METHODS: Blood samples before treatment, 10=3 days and 31 months of treatments were taken from 132 psychotic disorder patients in treatment. Serum alpha-GST was measured by Enzyme Linked Immunosorbent Assay (ELISA) and GSTs gene polymorphisms were genotyped, by Pcilymerase Chain Reaction. RESULTS: Our data indicated that alpha-GST might be a btomarket lbr liver injury and GSTs gene polymorphisms had a contribution to the risk of psychotic disorders. CONCLUSIONS: Our results encourage making research on finding more specific biomarker and individual susceptibility with larger sample size.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [113S508]; Gazi University Scientific Research project [02/2012-38]en_US
dc.description.sponsorshipThis study was supported by a grant from the Scientific and Technological Research Council of Turkey (113S508) and Gazi University Scientific Research (02/2012-38) projecten_US
dc.identifier.endpage71en_US
dc.identifier.issn0374-9320
dc.identifier.issn1827-1731
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84994291426en_US
dc.identifier.startpage62en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17880
dc.identifier.volume57en_US
dc.identifier.wosWOS:000398251000002en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherEdizioni Minerva Medicaen_US
dc.relation.ispartofMinerva Psichiatricaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntipsychotie Agentsen_US
dc.subjectPsychotic Disordersen_US
dc.subjectGlutathione S-Transferase Alphaen_US
dc.subjectPolymorphism, Geneticen_US
dc.subjectPolymerase Chain Reactionen_US
dc.titleAlpha-glutathione-s-transferase can be a biomarker for both drug-related toxicity as well as individual susceptibilityen_US
dc.typeArticleen_US

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