Progressive Loss of Corneal and Retinal Nerve Fibers in Patients With Multiple Sclerosis: A 2-Year Follow-up Study
Küçük Resim Yok
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Assoc Research Vision Ophthalmology Inc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Purpose: To determine longitudinal alterations in corneal nerve fiber morphology, dendritic cell (DC) density, and retinal nerve fiber layer (RNFL) thickness over 2 years in patients with multiple sclerosis (MS). Methods: Thirty-one consecutive patients with relapsing-remitting MS (RRMS) underwent assessment of the Kurtzke Expanded Disability Status Scale (EDSS), Multiple Sclerosis Severity Score (MSSS), corneal confocal microscopy to quantify corneal subbasal nerve morphology and DC density, and spectral-domain optical coherence tomography to quantify RNFL thickness at baseline and after 2 years. Results: There was a significant reduction in corneal nerve fiber area (CNFA) (P = 0.003), nerve fiber width (CNFW) (P = 0.005), and RNFL thickness (P = 0.004) with an increase in EDSS (P = 0.01) over 2 years. The change in corneal nerve fiber density (CNFD) correlated with the change in EDSS (rho = -0.468; P = 0.008), MSSS (rho = -0.442; P = 0.01), DC density (rho = -0.550; P = 0.001), and RNFL (rho = 0.472; P = 0.007). The change in corneal nerve fiber length (CNFL) correlated with the change in EDSS (rho = -0.445; P = 0.01) and MSSS (rho = -0.490; P = 0.005). Furthermore, there was a significant decrease in CNFL (P < 0.001), CNFA (P = 0.02), CNFW (P = 0.04), corneal total branch density (P = 0.01), and RNFL thickness (P = 0.02) and a significant increase in DC density (P = 0.04) in patients with worsening EDSS (n = 15). Conclusions: Corneal confocal microscopy can be used to detect progressive corneal nerve fiber loss that relates to a progression of disability in patients with RRMS. Translational Relevance: Corneal confocal microscopy acts as a sensitive imaging biomarker for progressive nerve degeneration in patients with MS.
Açıklama
Anahtar Kelimeler
Corneal Confocal Microscopy, Dendritic Cells, Multiple Sclerosis, Nerve Degeneration, Retinal Nerve Fiber Layer
Kaynak
Translational Vision Science & Technology
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
9
Sayı
13
