Progressive Loss of Corneal and Retinal Nerve Fibers in Patients With Multiple Sclerosis: A 2-Year Follow-up Study

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dc.contributor.authorBitirgen, Gulfidan
dc.contributor.authorAkpinar, Zehra
dc.contributor.authorUca, Ali Ulvi
dc.contributor.authorOzkagnici, Ahmet
dc.contributor.authorPetropoulos, Ioannis N.
dc.contributor.authorMalik, Rayaz A.
dc.date.accessioned2024-02-23T14:26:47Z
dc.date.available2024-02-23T14:26:47Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractPurpose: To determine longitudinal alterations in corneal nerve fiber morphology, dendritic cell (DC) density, and retinal nerve fiber layer (RNFL) thickness over 2 years in patients with multiple sclerosis (MS). Methods: Thirty-one consecutive patients with relapsing-remitting MS (RRMS) underwent assessment of the Kurtzke Expanded Disability Status Scale (EDSS), Multiple Sclerosis Severity Score (MSSS), corneal confocal microscopy to quantify corneal subbasal nerve morphology and DC density, and spectral-domain optical coherence tomography to quantify RNFL thickness at baseline and after 2 years. Results: There was a significant reduction in corneal nerve fiber area (CNFA) (P = 0.003), nerve fiber width (CNFW) (P = 0.005), and RNFL thickness (P = 0.004) with an increase in EDSS (P = 0.01) over 2 years. The change in corneal nerve fiber density (CNFD) correlated with the change in EDSS (rho = -0.468; P = 0.008), MSSS (rho = -0.442; P = 0.01), DC density (rho = -0.550; P = 0.001), and RNFL (rho = 0.472; P = 0.007). The change in corneal nerve fiber length (CNFL) correlated with the change in EDSS (rho = -0.445; P = 0.01) and MSSS (rho = -0.490; P = 0.005). Furthermore, there was a significant decrease in CNFL (P < 0.001), CNFA (P = 0.02), CNFW (P = 0.04), corneal total branch density (P = 0.01), and RNFL thickness (P = 0.02) and a significant increase in DC density (P = 0.04) in patients with worsening EDSS (n = 15). Conclusions: Corneal confocal microscopy can be used to detect progressive corneal nerve fiber loss that relates to a progression of disability in patients with RRMS. Translational Relevance: Corneal confocal microscopy acts as a sensitive imaging biomarker for progressive nerve degeneration in patients with MS.en_US
dc.identifier.doi10.1167/tvst.9.13.37
dc.identifier.issn2164-2591
dc.identifier.issue13en_US
dc.identifier.pmid33384891en_US
dc.identifier.scopus2-s2.0-85099402420en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1167/tvst.9.13.37
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14338
dc.identifier.volume9en_US
dc.identifier.wosWOS:000617720000004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssoc Research Vision Ophthalmology Incen_US
dc.relation.ispartofTranslational Vision Science & Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCorneal Confocal Microscopyen_US
dc.subjectDendritic Cellsen_US
dc.subjectMultiple Sclerosisen_US
dc.subjectNerve Degenerationen_US
dc.subjectRetinal Nerve Fiber Layeren_US
dc.titleProgressive Loss of Corneal and Retinal Nerve Fibers in Patients With Multiple Sclerosis: A 2-Year Follow-up Studyen_US
dc.typeArticleen_US

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