Association of Tumor Necrosis Factor Alpha -238G/A and -308G/A Promotor Polymorphisms with Clearance of Hepatitis B Virus Infection in Turkish Population

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dc.authoridAhmet Çağkan İnkaya: 0000-0001-7943-8715
dc.authoridİbrahim Erayman: 0000-0002-7491-2710
dc.authoridEmel Türk Arıbaş: 0000-0002-4551-4131
dc.authoridBahar Kandemir: 0000-0002-9815-8767
dc.authoridHasan Acar: 0000-0003-1888-2657
dc.contributor.authorİnkaya, Ahmet Çağkan
dc.contributor.authorTürk Arıbaş, Emel
dc.contributor.authorErayman, İbrahim
dc.contributor.authorKandemir, Bahar
dc.contributor.authorAcar, Hasan
dc.contributor.authorBitirgen, Mehmet
dc.date.accessioned2020-01-18T21:12:17Z
dc.date.available2020-01-18T21:12:17Z
dc.date.issued2019
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalıen_US
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Genetik Anabilim Dalıen_US
dc.description.abstractObjectives: Acute viral hepatitis B may lead to chronic hepatitis in 6% of adultpopulation. We compared the frequency of Tumor necrosis factor alpha promotor polymorphisms in chronic hepatitis B patients and people with natural immunity against hepatitis B.Materials and Methods: Chronic hepatitis B patients and age matched control cases with natural immunity to hepatitis B virus were recruited 1:1 in this study. Tumornecrosis factor alpha -238G/A and -308G/A polymorphisms were studied withPCR-RFLP. ?2 test was performed in statistical analysis.Results: A total of 101 volunteers enrolled in two study groups. Thirty-eight menand 12 women constituted the chronic hepatitis B patient group and 40 men and11 women recruited in natural immunity group. Frequency of -238G allele was87.5% and 97% in chronic hepatitis B and natural immunity groups, respectively.Frequency of -308G allel was 93% and 92.1% in chronic hepatitis B and natural im-munity groups, respectively. Frequencies of polymorphisms at positions -238 and-308 in the promotor of tumor necrosis factor alpha gene were not different be-tween chronic hepatitis B and natural immunity groups.Discussion: Tumor necrosis factor alpha promoter polymorphisms at -238 and-308 positions do not effect the outcome hepatitis B infection in Turkish population. Clearance of hepatitis B virus infection is multifactorial. Thus, further studiesneeded to identify genetic predisposition to chronic hepatitis B infection.en_US
dc.identifier.citationErayman, İ., Kandemir, B., Acar, H., İnkaya, A. Ç., Türk Arıbaş, E., Bitirgen, M. (2019). Association of tumor necrosis factor alpha -238g/a and -308g/a promotor polymorphisms with clearance of hepatitis b virus ınfection in turkish population. Acta Medica, 50, 1, 1-6.en_US
dc.identifier.endpage6en_US
dc.identifier.issn2147-9488en_US
dc.identifier.issue1en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpFME1qQXhNUT09/association-of-tumor-necrosis-factor-alpha-238g-a-and-308g-a-promotor-polymorphisms-with-clearance-of-hepatitis-b-virus-infection-in-turkish-population
dc.identifier.urihttps://hdl.handle.net/20.500.12452/2743
dc.identifier.volume50en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofActa Medicaen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcil Tıpen_US
dc.subjectHepatitis B virus
dc.subjectTumor necrosis factor alpha promoter polymorphism
dc.subjectGenetic predisposition to chronic hepatitis B infection
dc.titleAssociation of Tumor Necrosis Factor Alpha -238G/A and -308G/A Promotor Polymorphisms with Clearance of Hepatitis B Virus Infection in Turkish Populationen_US
dc.typeArticleen_US

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