The role of oxidative stress in ?-amanitin-induced hepatotoxicity in an experimental mouse model

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dc.authorid0000-0001-6431-5800en_US
dc.authorid0000-0002-9420-6514en_US
dc.authorid0000-0002-7729-7557en_US
dc.authorid0000-0003-3844-4785en_US
dc.authorid0000-0003-3273-671Xen_US
dc.authorid0000-0002-3308-5843en_US
dc.contributor.authorDündar, Zerrin Defne
dc.contributor.authorErgin, Mehmet
dc.contributor.authorKılınç, İbrahim
dc.contributor.authorÇolak, Tamer
dc.contributor.authorOltulu, Pembe
dc.contributor.authorCander, Başar
dc.date.accessioned2020-01-18T21:02:52Z
dc.date.available2020-01-18T21:02:52Z
dc.date.issued2017
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Acil Tıp Anabilim Dalıen_US
dc.departmentNEÜ, Meram Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Anabilim Dalıen_US
dc.departmentNEÜ, Meram Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Anabilim Dalıen_US
dc.description.abstractBackground/aim: This study aimed to evaluate oxidative stress markers of liver tissue in a mouse α-amanitin poisoning model with three different toxin levels. Materials and methods: The mice were randomly divided into Group 1 (control), Group 2 (0.2 mg/kg), Group 3 (0.6 mg/kg), and Group 4 (1.0 mg/kg). The toxin was injected intraperitoneally and 48 h of follow-up was performed before sacrifice. Results: Median superoxide dismutase activities of liver tissue in Groups 3 and 4 were significantly higher than in Group 1 (for both, P 0.001). The catalase activity in Group 2 was significantly higher, but in Groups 3 and 4 it was significantly lower than in Group 1 (for all, P 0.001). The glutathione peroxidase activities in Groups 2, 3, and 4 were significantly higher than in Group 1 (P 0.006, P 0.001, and P 0.001, respectively). The malondialdehyde levels of Groups 3 and 4 were significantly higher than Group 1 (P 0.015 and P 0.003, respectively). The catalase activity had significant correlations with total antioxidant status and total oxidant status levels (r 0.935 and r 0.789, respectively; for both, P > 0.001). Conclusion: Our findings support a significant role for increased oxidative stress in α-amanitin-induced hepatotoxicity.en_US
dc.identifier.citationDündar, Z. D., Ergin, M., Kilinç, I., Çolak, T., Oltulu, P., Cander, B. (2017). The role of oxidative stress in α-amanitin-induced hepatotoxicityin an experimental mouse model. Turkish Journal of Medical Sciences, 47, 1, 318-325.en_US
dc.identifier.doi10.3906/sag-1503-163en_US
dc.identifier.endpage325en_US
dc.identifier.issn1300-0144en_US
dc.identifier.issn1303-6165en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage318en_US
dc.identifier.urihttp://app.trdizin.gov.tr/publication/paper/detail/TWpVek1UWXpNdz09
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1328
dc.identifier.volume47en_US
dc.identifier.wosWOS:000395632600046en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCerrahien_US
dc.subjectAmanitinen_US
dc.subjectOxidative Stressen_US
dc.subjectMushroom Poisoningen_US
dc.subjectBiomarkeren_US
dc.subjectMouseen_US
dc.titleThe role of oxidative stress in ?-amanitin-induced hepatotoxicity in an experimental mouse modelen_US
dc.typeArticleen_US

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