Ocular Surface in Patients with Obstructive Sleep Apnea Syndrome: Evaluation of Clinical Parameters and Impression Cytology

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dc.authoridRefik Oltulu : 0000-0003-2447-6524en_US
dc.authoridPembe Oltulu : 0000-0003-3273-671Xen_US
dc.authoridŞebnem Yosunkaya : 0000-0002-7859-8941en_US
dc.contributor.authorGüneş, İrem
dc.contributor.authorOltulu, Refik
dc.contributor.authorOltulu, Pembe
dc.contributor.authorTürk, Nazlı
dc.contributor.authorYosunkaya, Şebnem
dc.date.accessioned2023-02-07T08:33:57Z
dc.date.available2023-02-07T08:33:57Z
dc.date.issued2023en_US
dc.departmentNEÜ, Meram Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göğüs Cerrahisi Anabilim Dalıen_US
dc.descriptionWOS:000901834600003en_US
dc.descriptionPubMed ID:36138005en_US
dc.description.abstractPurpose:To evaluate the effect of obstructive sleep apnea syndrome (OSAS) on the ocular surface and conjunctival cytology and the relationship between the findings and disease severity.Methods:One hundred six eyes of 106 patients (77 patients with OSAS and 29 control subjects) were included in the study. Twenty-three patients with an apnea-hypopnea index (AHI) of 5 to 15 were classified as mild OSAS (group 1), 27 patients with an AHI of 15 to 30 were classified as moderate OSAS (group 2), and 27 patients with an AHI >= 30 were classified as severe OSAS (group 3). The following tests were used to evaluate the ocular surface: tear break-up time (TBUT), Schirmer I test, ocular surface disease index (OSDI), and conjunctival impression cytology (CIC). The results obtained from the tests were analyzed and compared between the groups.Results:The mean value of the Schirmer I test was 15.03 +/- 10.16 (1-35) mm in the control group, whereas it was found as 13.39 +/- 8.80 (3-35) mm, 9.85 +/- 7.81 (1-30) mm, and 9.41 +/- 7.53 (2-35) mm in the mild, moderate, and severe OSAS groups, respectively, and the difference between the groups was significant (P=0.002). Although the mean TBUT score was 9.83 +/- 5.03 (3-23) seconds in the control group, it was 11.04 +/- 6.22 (3-20), 6.26 +/- 3.48 (1-16), and 5.44 +/- 3.09 (1-10) in the mild, moderate, and severe OSAS groups, respectively, and the difference between the groups was significant (P<0.001). Although the mean OSDI score was 12.76 +/- 14.84 (range, 0-41.65) in the control group, it was 11.52 +/- 12.95 (range, 0-44.40), 25.06 +/- 19.45 (range, 0-75), and 20.31 +/- 19.87 (range, 0-77.70) in the mild, moderate, and severe OSAS groups, respectively, and the difference between the groups was significant (P=0.015). Although the mean CIC stage was 0.47 +/- 0.60 (0-2) in the control group, it was 0.89 +/- 0.74 (0-2), 1.52 +/- 0.75 (0-3), and 1.83 +/- 0.69 (1-3) in the mild, moderate, and severe OSAS groups, respectively, and the difference between groups was significant (P<0.001).Conclusion:In addition to decreased tear production and TBUT, cytological changes including squamous metaplasia were detected between patients with OSAS and the control group.en_US
dc.description.sponsorshipNecmettin Erbakan University Meram Faculty of Medicineen_US
dc.identifier.citationGüneş, İ., Oltulu, R., Oltulu, P., Türk, N., Yosunkaya, Ş. (2023). Ocular surface in patients with obstructive sleep apnea syndrome: Evaluation of clinical parameters and impression cytology. Eye & Contact Lens-Science And Clinical Practice, 49, 1, 14-18.en_US
dc.identifier.doi10.1097/ICL.0000000000000945en_US
dc.identifier.endpage18en_US
dc.identifier.issn1542-2321en_US
dc.identifier.issn1542-233Xen_US
dc.identifier.issue1en_US
dc.identifier.pmid36138005en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage14en_US
dc.identifier.urihttp://dx.doi.org/10.1097/ICL.0000000000000945
dc.identifier.urihttps://hdl.handle.net/20.500.12452/9172
dc.identifier.volume49en_US
dc.identifier.wosWOS:000901834600003en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofEye & Contact Lens-Science and Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccesseng_US
dc.subjectDry Eye Diseaseen_US
dc.subjectObstructive Sleep Apnea Syndromeen_US
dc.subjectTear Break-Up Timeen_US
dc.subjectSchirmer I Testen_US
dc.subjectConjunctival Impression Cytologyen_US
dc.titleOcular Surface in Patients with Obstructive Sleep Apnea Syndrome: Evaluation of Clinical Parameters and Impression Cytologyen_US
dc.typeArticleen_US

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