Fluorescent silica nanoparticles as nano-chemosensors for the sequential detection of Pb2+ions and bacterial-spore biomarker dipicolinic acid (DPA) in aqueous solution
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Herein, we report fluorescein-labelled silica nanoparticles (FSNP) which serve as fluorescent nano-chemosensors for sequential detection of Pb2+ (which is a toxic heavy metal) and dipicolinic acid (DPA) (which is a distinctive indicator biomarker of bacterial spores) with high sensitivity and selectivity. The fluorescence of FSNP is quenched because of the complex formation between Pb2+ ions and surface amide groups, however, the fluorescence is recovered in contact with DPA, resulting from the association of DPA with surface bound Pb2+ ions. FSNP-Pb2+ complexes show high sensitivity towards DPA with a low detection limit of 850 nM which is approximately seventy times lower than the infectious dosage of bacterial spores (60 & mu;M). Lateral flow test platform was further developed to show the applicability and practicability of our system.
Açıklama
Anahtar Kelimeler
Bacterial Spores, Dipicolinic Acid, Pb2+, Silica Nanoparticles, Fluorescence, Lateral Flow
Kaynak
Spectrochimica Acta Part A-Molecular And Biomolecular Spectroscopy
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
303
