Fluorescent silica nanoparticles as nano-chemosensors for the sequential detection of Pb2+ions and bacterial-spore biomarker dipicolinic acid (DPA) in aqueous solution

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dc.contributor.authorCetinkaya, Yagmur Nur
dc.contributor.authorBulut, Onur
dc.contributor.authorOktem, Huseyin Avni
dc.contributor.authorYilmaz, M. Deniz
dc.date.accessioned2024-02-23T14:16:11Z
dc.date.available2024-02-23T14:16:11Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractHerein, we report fluorescein-labelled silica nanoparticles (FSNP) which serve as fluorescent nano-chemosensors for sequential detection of Pb2+ (which is a toxic heavy metal) and dipicolinic acid (DPA) (which is a distinctive indicator biomarker of bacterial spores) with high sensitivity and selectivity. The fluorescence of FSNP is quenched because of the complex formation between Pb2+ ions and surface amide groups, however, the fluorescence is recovered in contact with DPA, resulting from the association of DPA with surface bound Pb2+ ions. FSNP-Pb2+ complexes show high sensitivity towards DPA with a low detection limit of 850 nM which is approximately seventy times lower than the infectious dosage of bacterial spores (60 & mu;M). Lateral flow test platform was further developed to show the applicability and practicability of our system.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [120Z945]; Konya Food and Agriculture University (KFAU); Nanobiz R amp; D Ltd.; Nanobiz R amp; D Ltd.en_US
dc.description.sponsorshipThis research was financially supported by the Scientific and Technological Research Council of Turkey (TUBITAK), Project No: 120Z945, which is gratefully acknowledged here. We would also like to thank Konya Food and Agriculture University (KFAU) and Nanobiz R & D Ltd. for their support of this research.en_US
dc.identifier.doi10.1016/j.saa.2023.123222
dc.identifier.issn1386-1425
dc.identifier.issn1873-3557
dc.identifier.pmid37542871en_US
dc.identifier.scopus2-s2.0-85169883742en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.saa.2023.123222
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12551
dc.identifier.volume303en_US
dc.identifier.wosWOS:001071309600001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofSpectrochimica Acta Part A-Molecular And Biomolecular Spectroscopyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBacterial Sporesen_US
dc.subjectDipicolinic Aciden_US
dc.subjectPb2+en_US
dc.subjectSilica Nanoparticlesen_US
dc.subjectFluorescenceen_US
dc.subjectLateral Flowen_US
dc.titleFluorescent silica nanoparticles as nano-chemosensors for the sequential detection of Pb2+ions and bacterial-spore biomarker dipicolinic acid (DPA) in aqueous solutionen_US
dc.typeArticleen_US

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