The role of decoy receptor 3 in inflammation and atherosclerosis in patients with chronic kidney disease and renal transplant patients
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Soc Espanola Nefrologia Dr Rafael Matesanz
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Introduction: The cardiovascular risk has been increased in chronic kidney disease associated with chronic inflammation and atherosclerosis. Decoy receptor 3, is a member of the TNF receptor superfamily and associated with inflammation and atherosclerosis. The aim of our study is to determine the relationship, between serum DcR3 levels and inflammatory markers in patients with renal transplantation, those receiving dialysis treatment and cases with chronic renal failure that did not receive replacement therapy, and to evaluate their correlation with USG findings. Material and methods: A total of 150 patients aged between 22-86 years, consisting of 4 groups, namely renal transplantation, dialysis, predialysis chronic kidney disease and control groups, were included in the study. Serum decoy receptor 3, VCAM-1, ICAM-1 and IL-8 measured with ELISA method. Carotid intima-media thickness and presence of carotis arter plaque performed by ultrasound probe, non-invasively. Results: All serum markers were higher in dialysis and pre-dialysis chronic kidney disease groups compared to renal transplant and control groups (p < 0.05). Serum decoy receptor 3 level (median(min-max)) of renal transplant group (0.49 ng/mL (0.19-1.65)) was higher than control group (0.35 ng/mL (0.19-2.22)). There was no difference between patients receiving dialysis (0.89 ng/mL (0.41-4.98)) and patients with pre-dialysis chronic kidney disease (0.71 ng/mL (0.29-1.68)). There was no difference between patient groups in terms of the presence of plaque. Conclusion: Although renal transplantation provides a significant improvement in the inflammatory process, not return completely. Inflammatory process associated with uremic milieu may predispose to atherosclerosis in patients with pre-dialysis chronic kidney disease and hemodialysis patients. (c) 2022 Sociedad Espanola de Nefrologia. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Açıklama
Anahtar Kelimeler
Atherosclerosis, Carotid Intima-Media Thickness, Decoy Receptor 3, Inflammation
Kaynak
Nefrologia
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
43
Sayı
3
