The role of decoy receptor 3 in inflammation and atherosclerosis in patients with chronic kidney disease and renal transplant patients

Basit Öğe Kaydı
dc.contributor.authorUysal, Saliha
dc.contributor.authorToker, Aysun
dc.contributor.authorTurkmen, Kultigin
dc.contributor.authorKeskin, Suat
dc.date.accessioned2024-02-23T14:49:36Z
dc.date.available2024-02-23T14:49:36Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractIntroduction: The cardiovascular risk has been increased in chronic kidney disease associated with chronic inflammation and atherosclerosis. Decoy receptor 3, is a member of the TNF receptor superfamily and associated with inflammation and atherosclerosis. The aim of our study is to determine the relationship, between serum DcR3 levels and inflammatory markers in patients with renal transplantation, those receiving dialysis treatment and cases with chronic renal failure that did not receive replacement therapy, and to evaluate their correlation with USG findings. Material and methods: A total of 150 patients aged between 22-86 years, consisting of 4 groups, namely renal transplantation, dialysis, predialysis chronic kidney disease and control groups, were included in the study. Serum decoy receptor 3, VCAM-1, ICAM-1 and IL-8 measured with ELISA method. Carotid intima-media thickness and presence of carotis arter plaque performed by ultrasound probe, non-invasively. Results: All serum markers were higher in dialysis and pre-dialysis chronic kidney disease groups compared to renal transplant and control groups (p < 0.05). Serum decoy receptor 3 level (median(min-max)) of renal transplant group (0.49 ng/mL (0.19-1.65)) was higher than control group (0.35 ng/mL (0.19-2.22)). There was no difference between patients receiving dialysis (0.89 ng/mL (0.41-4.98)) and patients with pre-dialysis chronic kidney disease (0.71 ng/mL (0.29-1.68)). There was no difference between patient groups in terms of the presence of plaque. Conclusion: Although renal transplantation provides a significant improvement in the inflammatory process, not return completely. Inflammatory process associated with uremic milieu may predispose to atherosclerosis in patients with pre-dialysis chronic kidney disease and hemodialysis patients. (c) 2022 Sociedad Espanola de Nefrologia. Published by Elsevier Espana, S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.identifier.endpage350en_US
dc.identifier.issn0211-6995
dc.identifier.issn1989-2284
dc.identifier.issue3en_US
dc.identifier.pmid36517358en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage344en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/18275
dc.identifier.volume43en_US
dc.identifier.wosWOS:001068572500009en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSoc Espanola Nefrologia Dr Rafael Matesanzen_US
dc.relation.ispartofNefrologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAtherosclerosisen_US
dc.subjectCarotid Intima-Media Thicknessen_US
dc.subjectDecoy Receptor 3en_US
dc.subjectInflammationen_US
dc.titleThe role of decoy receptor 3 in inflammation and atherosclerosis in patients with chronic kidney disease and renal transplant patientsen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu