Association of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Study

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dc.authoridHacı Hasan Esen: 0000-0002-8559-2476en_US
dc.contributor.authorKülahcı, Özgür
dc.contributor.authorEsen, Hacı Hasan
dc.contributor.authorAsut, Elife
dc.contributor.authorGüngör, Salim
dc.date.accessioned2020-01-18T21:12:12Z
dc.date.available2020-01-18T21:12:12Z
dc.date.issued2017
dc.departmentNEÜ, Meram Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Anabilim Dalıen_US
dc.descriptionWOS:000395502400002en_US
dc.descriptionPubMed ID:28331761en_US
dc.description.abstractObjective: Breast carcinoma is the most common malignant tumor detected in women. fte hypothesis that increased levels of adhesion molecules and Cathepsin D affect cancerous cells moving away the primary tumor and contributes to migration of the cancerous cell and may cause remote organ metastases is defended. fte aim of the present study was to search the association of intracellular adhesion molecule-1 (ICAM-1), vascular adhesion molecule-1 (VCAM-1), Cyclin D1, cathepsin D immunohistochemically with clinicopathological parameters in the patients diagnosed with invasive ductal breast carcinoma. Materials and Methods: fte pathological slides of 153 patients diagnosed with invasive ductal carcinoma were evaluated retrospectively. ftree groups were created. Group 1 consisted of patients with positive lymph node metastasis and extranodal tumor invasion; Group 2 consisted of patients with positive axillary lymph node metastasis and negative extranodal tumor invasion and Group 3 consisted of the patients with negative axillary lymph node metastasis. In all groups, 20 paraffin blocks belonging to the primary tumor in the breast were stained by ICAM-1, VCAM-1, Cyclin D1 and Cathepsin D. Findings were examined by comparing with clinicopathological parameters. Results: fte highest number of metastatic axillary lymph nodes and the highest rate of cathepsin D staining were statistically found in the cases with positive axillary lymph node metastasis and extranodal tumor invasion. CerbB2 was negative in the cases with negative ICAM-1 whereas estrogen receptor and progesterone receptor were positive in the cases with positive VCAM-1. Conclusion: fte present study reveals significant results for the patients diagnosed with invasive ductal carcinoma through breast biopsy especially before mastectomy in terms of increased number of metastatic axillary lymph nodes and extranodal tumor invasion by immunohistochemical Cathepsin D stain without any additional invasive intervention. Results of the present study may contribute to monitoring and treatment of the patients in the future.en_US
dc.identifier.citationEsen, H. H., Külahcı, O., Asut, E., Güngör, S. (2017). Association of ICAM-1, VCAM-1, CYCLIN D1 and cathepsin D with clinicopathological parameters in breast carcinoma; An immunohistochemical study. The Journal of Breast Health, 13, 1, 5-9.en_US
dc.identifier.doi10.5152/tjbh.2016.3142en_US
dc.identifier.endpage9en_US
dc.identifier.issn2149-1976en_US
dc.identifier.issue1en_US
dc.identifier.pmid28331761en_US
dc.identifier.startpage5en_US
dc.identifier.urihttps://dx.doi.org/10.5152/tjbh.2016.3142
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWprME1qTXdNQT09/association-of-icam-1-vcam-1-cyclin-d1-and-cathepsin-d-with-clinicopathological-parameters-in-breast-carcinoma-an-immunohistochemical-study
dc.identifier.urihttps://hdl.handle.net/20.500.12452/2723
dc.identifier.volume13en_US
dc.identifier.wosWOS:000395502400002en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofThe Journal of Breast Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBreast carcinomaen_US
dc.subjectCathepsin Den_US
dc.subjectİmmunohistochemistryen_US
dc.subjectMetastasisen_US
dc.titleAssociation of ICAM-1, VCAM-1, CYCLIN D1 and Cathepsin D with Clinicopathological Parameters in Breast Carcinoma; an Immunohistochemical Studyen_US
dc.typeArticleen_US

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