Clinical and laboratory evaluation of Turkish children with IgG subclass deficiency

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dc.authoridSelma Erol Aytekin: 0000-0001-6256-5988en_US
dc.authoridŞükrü Nail Güner: 0000-0002-8860-6132en_US
dc.authoridSevgi Keleş: 0000-0001-7344-8947en_US
dc.authoridİsmail Reisli: 0000-0001-8247-6405en_US
dc.contributor.authorKocaoğlu, Mehmet
dc.contributor.authorKocaoğlu, Burcu Ezgi
dc.contributor.authorAytekin, Selma Erol
dc.contributor.authorKeskin, Doğukan Mustafa
dc.contributor.authorGüner, Şükrü Nail
dc.contributor.authorKeleş, Sevgi
dc.contributor.authorReisli, İsmail
dc.date.accessioned2023-05-30T10:13:15Z
dc.date.available2023-05-30T10:13:15Z
dc.date.issued2023en_US
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Anabilim Dalıen_US
dc.descriptionMakaleen_US
dc.descriptionWOS:000922080700001en_US
dc.descriptionPubMed ID:36089538en_US
dc.description.abstractBackground: IgG subclass deficiency is a laboratory diagnosis and becomes important with recurrent infections. This study aimed to examine the demographic, clinical, and laboratory results of pediatric cases with IgG subclass deficiency and to improve the understanding of the clinical significance of IgG subclass deficiency. Methods: In this study, the clinical and laboratory features of 111 pediatric patients, with at least one whose serum IgG subclasses was measured as lower than 2 standard deviation of healthy aged-matched control values, were evaluated. The clinical and laboratory features of the cases with isolated IgG subclass deficiency (Group 1) and those with low serum levels of any of IgG, IgA, and IgM in addition to the IgG subclass deficiency (Group 2) were compared. Results: A total of 55 (49.54%) and 56 (50.45 %) patients were included in Groups 1 and 2, respectively. Among our studied cases, 20 (18. 1%) had a history of hospitalization in the neonatal period, 61 (54.95 %) had at least one hospitalization due to infection, and 55 (49.54%) had a history of recurrent infection. The frequencies of these three conditions were statistically significantly higher in Group 2 (p < 0.05). The frequencies of infections in the last year in Groups 1 and 2 were 4.4 +/- 1.2 and 5.4 +/- 1.9, respectively (p < 0.05). As a result of recurrent infections, 43.24% (n = 48) of our patients received antibiotic prophylaxis, and 21.62% (n = 24) had immunoglobulin replacement therapy. Furthermore, the numbers of pa-tients who needed these treatments were higher in Group 2 (p < 0.05).Conclusion: In cases with IgG subclass deficiencies, concomitant main-group immunoglobulin deficiencies may increase the number and severity of infections, leading to hospitalizations, antibiotic prophylaxis, and immunoglobulin therapy. More attention should be paid to cases of immunoglobulin main-group deficiencies in the follow-up of these cases.Copyright (c) 2022, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/ by-nc-nd/4.0/).en_US
dc.identifier.citationKocaoğlu, M., Kocaoğlu, B. E., Aytekin, S. E., Keskin, D. M., Güner, Ş. N., Keleş, S., Reisli, İ. (2023). Clinical and laboratory evaluation of Turkish children with IgG subclass deficiency. Pediatrics and Neonatology, 64, 1, 38-45.en_US
dc.identifier.doi10.1016/j.pedneo.2022.04.014en_US
dc.identifier.endpage45en_US
dc.identifier.issn1875-9572en_US
dc.identifier.issn2212-1692en_US
dc.identifier.issue1en_US
dc.identifier.pmid36089538en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage38en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.pedneo.2022.04.014
dc.identifier.urihttps://hdl.handle.net/20.500.12452/9739
dc.identifier.volume64en_US
dc.identifier.wosWOS:000922080700001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofPediatrics and Neonatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntibody Deficiencyen_US
dc.subjectChilden_US
dc.subjectIgG Subclass Deficiencyen_US
dc.titleClinical and laboratory evaluation of Turkish children with IgG subclass deficiencyen_US
dc.typeArticleen_US

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