Characteristics of the cornea in patients with pseudoexfoliation syndrome

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dc.contributor.authorOltulu, Refik
dc.contributor.authorSatirtav, Gunhal
dc.contributor.authorKayitmazbatir, Emine Tinkir
dc.contributor.authorBitirgen, Gulfidan
dc.contributor.authorOzkagnici, Ahmet
dc.contributor.authorKaraibrahimoglu, Adnan
dc.date.accessioned2024-02-23T14:44:46Z
dc.date.available2024-02-23T14:44:46Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractPurpose: To quantify the morphological alterations in corneal nerve fibers and cells in patients with pseudoexfoliation syndrome (PEX) and their relationship with the presence of hyperreflective endothelial deposits observed using in vivo confocal microscopy. Methods: One eye each of 37 patients with PEX and 20 age-matched healthy control subjects was evaluated by in vivo corneal confocal microscopy. Patients with PEX were further classified into two groups: those with and without hyperreflective endothelial deposits. We evaluated the densities of basal epithelial cells, anterior and posterior stromal keratocytes, and endothelial cells and structure of sub-basal nerve fibers. Results: The mean anterior and posterior stromal keratocyte and endothelial cell densities and corneal sub-basal nerve plexus variables were significantly lower in patients with PEX compared with those in healthy control subjects. The mean basal epithelial cell density did not significantly differ. Conclusion: Eyes with PEX presented decreased corneal sub-basal nerve plexus variables and cell densities in all corneas, except for the mean basal epithelial cell density. Further, a trend of lower corneal sub-basal nerve plexus measurements in patients with hyperreflective endothelial deposits compared with those without endothelial deposits was observed.en_US
dc.identifier.doi10.5935/0004-2749.20150092
dc.identifier.endpage351en_US
dc.identifier.issn0004-2749
dc.identifier.issn1678-2925
dc.identifier.issue6en_US
dc.identifier.pmid26677035en_US
dc.identifier.scopus2-s2.0-84953724130en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage348en_US
dc.identifier.urihttps://doi.org/10.5935/0004-2749.20150092
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17111
dc.identifier.volume78en_US
dc.identifier.wosWOS:000367095100005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherConsel Brasil Oftalmologiaen_US
dc.relation.ispartofArquivos Brasileiros De Oftalmologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCornea/Physiopathologyen_US
dc.subjectCornea/Innervationen_US
dc.subjectExfoliation Syndrome/Diagnosisen_US
dc.subjectConfocal Microscopyen_US
dc.subjectNerve Fibers/Pathologyen_US
dc.titleCharacteristics of the cornea in patients with pseudoexfoliation syndromeen_US
dc.typeArticleen_US

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