Moderate hypothermia attenuates ?1-adrenoceptor-mediated contraction in human varicose spermatic vein: The role of nitric oxide (Short communication)
Küçük Resim Yok
Tarih
2016
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Akademiai Kiado Rt
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The effects of moderate hypothermia (28 degrees C) on the response of human varicose spermatic vein to alpha(1)-adrenoceptor agonist phenylephrine and the role of endothelial nitric oxide (NO) in these effects were studied. Concentration-response curves for phenylephrine (10(-9) to 3 x 10(-4) M) were recorded in rings with and without endothelium at 37 and 28 degrees C. To further analyze the role of NO, in the response to phenylephrine during hypothermia, the effects of this agonist in the presence of N-G-nitro-L-arginine methyl ester (10(-4) M) were also determined. Under every condition tested, phenylephrine produced a marked, concentration-dependent contraction. Sensitivity of intact veins to the agonist was consistently lower at 28 degrees C than at 37 degrees C. There was no significant difference in phenylephrine response at 28 and 37 degrees C in vessels without endothelium but at 28 degrees C veins without endothelium showed a higher sensitivity than intact veins to phenylephrine. The sensitivity of veins with and without endothelium to nitroprusside (10(-9) to 3 x 10(-3) M) was significantly decreased during hypothermia, and endothelium removal did not affect the relaxation to this nitrovasodilator. These results suggest that moderate hypothermia decreases the sensitivity of human varicose spermatic vein to phenylephrine probably by increasing the availability of endothelial NO.
Açıklama
Anahtar Kelimeler
Endothelium, Hypothermia, No, Phenylephrine, Spermatic Vein, Temperature
Kaynak
Physiology International
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
103
Sayı
4
