Moderate hypothermia attenuates ?1-adrenoceptor-mediated contraction in human varicose spermatic vein: The role of nitric oxide (Short communication)

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dc.contributor.authorNurullahoglu-Atalik, K. E.
dc.contributor.authorCenker, A.
dc.date.accessioned2024-02-23T14:32:05Z
dc.date.available2024-02-23T14:32:05Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractThe effects of moderate hypothermia (28 degrees C) on the response of human varicose spermatic vein to alpha(1)-adrenoceptor agonist phenylephrine and the role of endothelial nitric oxide (NO) in these effects were studied. Concentration-response curves for phenylephrine (10(-9) to 3 x 10(-4) M) were recorded in rings with and without endothelium at 37 and 28 degrees C. To further analyze the role of NO, in the response to phenylephrine during hypothermia, the effects of this agonist in the presence of N-G-nitro-L-arginine methyl ester (10(-4) M) were also determined. Under every condition tested, phenylephrine produced a marked, concentration-dependent contraction. Sensitivity of intact veins to the agonist was consistently lower at 28 degrees C than at 37 degrees C. There was no significant difference in phenylephrine response at 28 and 37 degrees C in vessels without endothelium but at 28 degrees C veins without endothelium showed a higher sensitivity than intact veins to phenylephrine. The sensitivity of veins with and without endothelium to nitroprusside (10(-9) to 3 x 10(-3) M) was significantly decreased during hypothermia, and endothelium removal did not affect the relaxation to this nitrovasodilator. These results suggest that moderate hypothermia decreases the sensitivity of human varicose spermatic vein to phenylephrine probably by increasing the availability of endothelial NO.en_US
dc.identifier.doi10.1556/2060.103.2016.4.2
dc.identifier.endpage486en_US
dc.identifier.issn2498-602X
dc.identifier.issue4en_US
dc.identifier.pmid28229627en_US
dc.identifier.scopus2-s2.0-85015919542en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage481en_US
dc.identifier.urihttps://doi.org/10.1556/2060.103.2016.4.2
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15483
dc.identifier.volume103en_US
dc.identifier.wosWOS:000393134600007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAkademiai Kiado Rten_US
dc.relation.ispartofPhysiology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEndotheliumen_US
dc.subjectHypothermiaen_US
dc.subjectNoen_US
dc.subjectPhenylephrineen_US
dc.subjectSpermatic Veinen_US
dc.subjectTemperatureen_US
dc.titleModerate hypothermia attenuates ?1-adrenoceptor-mediated contraction in human varicose spermatic vein: The role of nitric oxide (Short communication)en_US
dc.typeArticleen_US

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