Tip 1 diabetli çocuk ve adölesanlarda galektin 3, ileriglikasyon son ürünleri (AGE), ve ileri glikasyon son ürünlerireseptörü (RAGE) seviyelerinin araştırılması
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Dosyalar
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Tip 1 diyabetli çocuk ve adölesanlarda galektin 3, ileri glikasyon son
ürünleri (AGE) ve ileri glikasyon son ürünleri reseptörü (RAGE) seviyelerinin
araştırılması ve bu moleküllerin birbiriyle ilişkisini incelemek.
Materyal ve Metot: Çalışmaya Necmettin Erbakan Üniversitesi Meram Tıp
Fakültesi hastanesine başvuran 37 tip 1 diyabet tanısı alan çocuk ve adölesan (19 K, 18
E) ve 35 herhangi bir hastalığı saptanmayan çocuk ve adölesan (21 K, 14 E) dahil edildi.
Galektin 3, AGE ve RAGE düzeyleri ELISA yöntemiyle ölçüldü. Sonuçların analizi
için SPSS IBM istatistik programından yararlanıldı.
Bulgular: Tip 1 diyabetli çocuk ve adölesanların galektin 3 [0,22 (0,18-0,41)] ve
AGE [10,83 (8,64-13,15)] düzeyleri kontrol grubunun galektin 3 [0,18 (0,15-0,25)] ve
AGE [8,13 (7,42-11,05)] düzeylerinden anlamlı olarak yüksekti (p<0,05). Tip 1
diyabetli çocuk ve adölesanların RAGE düzeyi (91,28±72,12) kontrol grubunun RAGE
(87,04±61,58) düzeyinden yüksek olmasına rağmen bu yükseklik anlamlı değildi
(p>0,05). Kontrol grubunda AGE ile galektin 3 (r=-0,343, p<0,05) arasında negatif
korelasyon saptandı ve galektin 3 ve RAGE arasında anlamlı bir korelasyon saptanmadı.
Hasta grubunda ise AGE ile galektin 3 (r=-0,346, p<0,05) arasında negatif korelasyon
bulundu. Fakat galektin 3 ile RAGE (r=0,536, p<0,01) arasında pozitif korelasyon
saptandı.
Sonuç: Çalışmamızda tip 1 diyabetli çocuk ve adölesanlarda kontrol grubundan
yüksek bulduğumuz galektin 3 düzeyleri, çocuk ve adölesanlardaki tip 1 diyabet
oluşumunda galektin 3’ün rolü olabileceğini düşündürmektedir. Çalışmamız tip 1
diyabetli çocuk ve adölesanlarda galektin 3 düzeyini araştıran ilk çalışmadır.
Çalışmamızın bu açıdan literatüre katkı yapacağını düşünüyoruz Galektin 3 tip 1
diyabet hastalığında önemli bir belirteç olabilir ve tip 1 diyabetin patogenezinde yeni
yolakların keşfedilmesinde de rol alabilir. Bunlar için tip 1 diyabet patogenezinde
galektin 3’ün aldığı rol ile AGE ve RAGE arasındaki ilişkinin daha sonra yapılacak
araştırmalarla desteklenerek açığa çıkarılması gerekmektedir
Purpose: To investigate the levels of galectin 3, advanced glycation products and receptor for advanced glycation products in children and adolescents with type 1 diabetes and to examine the relationship of these molecules with each other. Materials and Methods: The study included 37 children and adolescents (19 F, 18 M) who were diagnosed with type 1 diabetes and 35 children and adolescents (21 F, 14 M) who did not have any disease, who applied to the Necmettin Erbakan University Meram Medical Faculty Hospital. Galectin 3, AGE and RAGE levels were measured by ELISA method. SPSS IBM statistical program was used to analyze the results. Results: Galectin 3 [0.22 (0.18-0.41)] and AGE [10.83 (8.64-13.15)] levels in children and adolescents with type 1 diabetes mellitus significantly higher than galectin 3 [0.18 (0.15- 0.25)] and AGE [8.13 (7.42-11.05)] levels) in control group (p<0.05). Although the RAGE level (91.28±72.12) of children and adolescents with type 1 diabetes was higher than the RAGE (87.04±61.58) level of the control group, this elevation was not significant (p>0.05). Also, there was a negative correlation between AGE and galectin 3 (r=-0.343, p<0.05) in the control group, and no significant correlation was found between galectin 3 and RAGE. In the patient group, a negative correlation was found between AGE and galectin 3 (r=-0.346, p<0.05). However, a positive correlation was found between galectin 3 an RAGE (r=0.536, p<0.01). Conclusion: In our study, galectin 3 levels which we found higher in children and adolescents with type 1 diabetes than in the control group, suggest that galectin 3 may have a role in the formation of type 1 diabetes in children and adolescents. Our study is the first to investigate the level of galectin 3 in children and adolescents with type 1 diabetes. We think that our study will contribute to the literature in this respect. Galectin 3 may be an important marker in type 1 diabetes and it may also play a role in the discovery of new pathways in the pathogenesis of type 1 diabetes. For these, the role of galectin 3 in the pathogenesis of type 1 diabetes and its relationship between AGE and RAGE should be supported by further research
Purpose: To investigate the levels of galectin 3, advanced glycation products and receptor for advanced glycation products in children and adolescents with type 1 diabetes and to examine the relationship of these molecules with each other. Materials and Methods: The study included 37 children and adolescents (19 F, 18 M) who were diagnosed with type 1 diabetes and 35 children and adolescents (21 F, 14 M) who did not have any disease, who applied to the Necmettin Erbakan University Meram Medical Faculty Hospital. Galectin 3, AGE and RAGE levels were measured by ELISA method. SPSS IBM statistical program was used to analyze the results. Results: Galectin 3 [0.22 (0.18-0.41)] and AGE [10.83 (8.64-13.15)] levels in children and adolescents with type 1 diabetes mellitus significantly higher than galectin 3 [0.18 (0.15- 0.25)] and AGE [8.13 (7.42-11.05)] levels) in control group (p<0.05). Although the RAGE level (91.28±72.12) of children and adolescents with type 1 diabetes was higher than the RAGE (87.04±61.58) level of the control group, this elevation was not significant (p>0.05). Also, there was a negative correlation between AGE and galectin 3 (r=-0.343, p<0.05) in the control group, and no significant correlation was found between galectin 3 and RAGE. In the patient group, a negative correlation was found between AGE and galectin 3 (r=-0.346, p<0.05). However, a positive correlation was found between galectin 3 an RAGE (r=0.536, p<0.01). Conclusion: In our study, galectin 3 levels which we found higher in children and adolescents with type 1 diabetes than in the control group, suggest that galectin 3 may have a role in the formation of type 1 diabetes in children and adolescents. Our study is the first to investigate the level of galectin 3 in children and adolescents with type 1 diabetes. We think that our study will contribute to the literature in this respect. Galectin 3 may be an important marker in type 1 diabetes and it may also play a role in the discovery of new pathways in the pathogenesis of type 1 diabetes. For these, the role of galectin 3 in the pathogenesis of type 1 diabetes and its relationship between AGE and RAGE should be supported by further research
Açıklama
Anahtar Kelimeler
Galektin 3, AGE, RAGE, Tip 1 diyabet, Galectin 3, AGE, RAGE, Type 1 diabetes
Kaynak
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Döner, H. C. (2021). Tip 1 diabetli çocuk ve adölesanlarda galektin 3, ileriglikasyon son ürünleri (AGE), ve ileri glikasyon son ürünlerireseptörü (RAGE) seviyelerinin araştırılması. (Yayınlanmamış tıpta uzmanlık tezi) Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi Temel Tıp Bilimleri Bölümü Tıbbi Biyokimya Anabilim Dalı, Konya.
