Evre I-II Hipertansif Bireylerde Kan Basıncı Düzenlemesinin Arteryel Sertlik Üzerine Etkisi
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Tarih
2013
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info:eu-repo/semantics/openAccess
Özet
Amaç: Hipertansif hastalarda sub-klinik organ hasarı göstergelerinden biri de arteryel sertliktir. Çalışmamızda Evre I-II hipertansiflerde kan basıncı düzenlemesinin arteryel sertlik üzerine etkilerini değerlendirdik. Gereç ve Yöntem: 18-65 yaş Evre I-II hipertansif 60 (34 Evre I, 26 Evre II) hastaya tedavi öncesi ve en az bir ay sonrası olmak üzere 24 saatlik ayaktan kan basıncı izlemi yapıldı. Hastaların tedavileri, arteryel sertlik parametrelerine kör olan hastanın kendi doktorunca verildi. Kan basıncı kontrol altına alınan (Grup 1, n30) ve alınamayan (Grup 2, n30) olarak iki grup oluşturuldu. 24 saatlik holter izleminden hesaplanan aortik sertlik parametrelerinin her iki grupta tedavi öncesi ve sonrası değerleri karşılaştırıldı. Bulgular: Tedavi sonrası; grup 1 hastaların kan basınçları ve arteryel sertlik parametrelerinde [Augmentasyon basıncı (13,46, 10.75.6, p0.001), Augmentasyon indeksi (29,68,2, 26,08,0, p0.001), nabız basıncı (479, 416, p0,001), nabız dalga hızı (7.70.9, 7.10.9, p0.001)] anlamlı düşme izlendi (p0,05). Grup 2 hastaların ortalama diyastolik kan basıncı (948, 918, p0,01) ile kalp hızında (788, 748, p0,03) anlamlı düşme, Augmentasyon basıncında (12,05,1, 14,05,9, p.03) anlamlı yükselme (p0,05) izlenirken, diğer parametrelerde anlamlı değişim görülmedi. Sonuç: Evre I ve Evre II hipertansif hastalarda kan basıncı kontrolü, arteryel sertlik parametrelerinde anlamlı düzelme sağlamaktadır. Yeterli kan basıncı kontrolünün sağlanamadığı durumda ise antihipertansiflere rağmen arteryel sertlik parametreleri düzelmemektedir.
Aim: One of the indicators of sub-clinical organ damage in hypertensive patients is also arterial stiffness. We evaluated the effects of blood pressure regulation on arterial stiffness in stage I-II hypertensives. Material and Method: A total of 60 patients ageing 18-65 with stage I-II hypertension (34 stage I, 26 stage II) underwent 24-hour ambulatory blood pressure monitoring before and at least one month later treatment. The treatments were performed by their physi- cians who blind to parameters of arterial stiffness. Two groups were generated including blood pressure regulated- (Group 1, n30) and non-regulated (Group 2, n30). Aortic stiffness parameters, calculated by 24-hour monitoring, before and after treatment were compared in both groups. Results: After treatment, the blood pressures and arterial stiffness parameters [Augmentation pressure (13.4±6, 10.7±5.6, p>0.001), Augmentation index (29.6±8.2, 26.0±8.0, p0.001), pulse pressure (47±9, 41±6, p>0.001), pulse wave velocity (7.7±0.9, 7.1±0.9, p>0.001)] of group 1 were significantly decreased. Whereas mean diastolic blood pressures and heart rates of group 2 were significantly decreased, augmentation pressure was significantly increased, other parameters did not change significantly. Conclusion: Blood pressure regulation resulted in statistically significant improve of arterial stiffness parameters in stage I-II hypertension. When blood pressure could be not regulated, aortic stiffness parameters wasnt improved despite using the antihypertensive drugs.
Aim: One of the indicators of sub-clinical organ damage in hypertensive patients is also arterial stiffness. We evaluated the effects of blood pressure regulation on arterial stiffness in stage I-II hypertensives. Material and Method: A total of 60 patients ageing 18-65 with stage I-II hypertension (34 stage I, 26 stage II) underwent 24-hour ambulatory blood pressure monitoring before and at least one month later treatment. The treatments were performed by their physi- cians who blind to parameters of arterial stiffness. Two groups were generated including blood pressure regulated- (Group 1, n30) and non-regulated (Group 2, n30). Aortic stiffness parameters, calculated by 24-hour monitoring, before and after treatment were compared in both groups. Results: After treatment, the blood pressures and arterial stiffness parameters [Augmentation pressure (13.4±6, 10.7±5.6, p>0.001), Augmentation index (29.6±8.2, 26.0±8.0, p0.001), pulse pressure (47±9, 41±6, p>0.001), pulse wave velocity (7.7±0.9, 7.1±0.9, p>0.001)] of group 1 were significantly decreased. Whereas mean diastolic blood pressures and heart rates of group 2 were significantly decreased, augmentation pressure was significantly increased, other parameters did not change significantly. Conclusion: Blood pressure regulation resulted in statistically significant improve of arterial stiffness parameters in stage I-II hypertension. When blood pressure could be not regulated, aortic stiffness parameters wasnt improved despite using the antihypertensive drugs.
Açıklama
Anahtar Kelimeler
Hipertansiyon, Hipertansiyon, Arteryel sertlik, Ambulatuvar kan basıncı monitorizasyonu, Hypertension, Arterial stiffness, Ambulatory blood pressure monitoring
Kaynak
MN Kardiyoloji
WoS Q Değeri
Scopus Q Değeri
Cilt
20
Sayı
3
Künye
Arıbaş, A., Altunkeser, B. B., Arıbaş, F. Z., Avcı, A., Demir, K., Aygül, N. (2013). Evre I-II hipertansif bireylerde kan basıncı düzenlemesinin arteryel sertlik üzerine etkisi. MN Kardiyoloji, 20, 3, 125-132.
