Psoriasisli Hastalarda Serum Nöroinflamatuvar Belirteç Seviyeleri ve Geniş Çaplı Periferik Sinir Lifi Fonksiyonlarının Değerlendirilmesi
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Tarih
2016
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Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Günümüzde tümör nekroz faktör-alfa (TNF-?) inhibitörleri, özellikle şiddetli psoriasisin tedavisinde tüm dünyada yaygın olarak kullanılmaktadırlar. Ancak psoriasisli hastalarda TNF-? inhibitör tedavisiyle ilişkilendirilmiş multipl sklerozis (MS) ve periferal nöropatiler bildirilmektedir. Psoriasis tedavisinde kullanılan TNF-? inhibitörleri, altta yatan nörolojik bozukluğu ortaya çıkarıp çıkarmadığı bilinmemektedir. Bu çalışmanın amacı; psoriasis ile multipl sklerozis ve periferal nöropatiler arasında bağlantı olup olmadığını araştırmaktır. Yöntemler: Bu çalışmada; 50 psoriasisli hasta ve 25 sağlıklı kontrol çalışmaya alındı. Nörolojik muayene ve iğne elektromiyografi testleri uygulandı. Nöroinflamatuvar süreçte rol alan matriks metalloproteinaz-2 (MMP-2), matriks metalloproteinaz-9 (MMP-9), S100 kalsiyum bağlayıcı protein (S100B) ve nöron spesifik enolaz (NSE) seviyeleri serumda ölçüldü. Bulgular: Sağlıklı kontrol grubu ile karşılaştırıldığında serum MMP-9 seviyeleri psoriasisli hastalarda yüksek tespit edilirken MMP-2 ve NSE seviyeleri psoriasisli hastalarda, sağlıklı kontrollere göre düşük tespit edildi. Serum S100B seviyeleri açısından her 2 grup arasında fark yoktu. Tüm hastalarda ve sağlıklı kontrollerde tüm nörofizyolojik parametreler normal bulundu ve 2 grup arasında fark tespit edilmedi. Sonuç: NSE ve MMP-9, psoriasisli hastalarda MS'in oluşmasında rol oynuyor olabilir. Özellikle ailesel MS öyküsü olan psoriasisli hastalarda, TNF-? inhibitörü ajan başlamadan önce bu belirteçlerin ölçülmesinin faydalı olabileceğini düşünüyoruz.
Objective: Currently, tumor necrosis factor- alpha (TNF-?) inhibitors are widely used all over the world, especially in the treatment of severe psoriasis. However, multiple sclerosis (MS) and peripheral neuropathy occurrence associated with TNF-? inhibitors have been reported in the treatment of patients with psoriasis. It is not known whether TNF-? inhibitors reveal underlying neurological disorders in patients with psoriasis. The aim of this study was to investigate whether there is an association between psoriasis and MS or peripheral neuropathy.Methods: In this study, 50 psoriasis patients and 25 healthy controls were enrolled. Neurological examination and needle electromyography test were performed. Serum levels of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), S-100 calcium-binding protein (S100B) and neuron specific enolase (NSE), which are involved in neuroinflammatory process, were measured. Results: Serum MMP-9 levels were higher in psoriasis patients compared to healthy controls. Serum MMP-2 and NSE levels were decreased in psoriasis patients compared to healthy controls. There was no significant difference in S100B levels between two groups. All neurophysiological parameters in each individual patient and control were found to be within normal limits and there was no difference between groups. Conclusion: NSE and MMP-9 might play role in the occurrence of MS in psoriasis patients. Especially, we are in the opinion that it might be useful to measure the serum levels of these markers before the administration of TNF-? inhibitors in psoriasis patients with family history of MS.
Objective: Currently, tumor necrosis factor- alpha (TNF-?) inhibitors are widely used all over the world, especially in the treatment of severe psoriasis. However, multiple sclerosis (MS) and peripheral neuropathy occurrence associated with TNF-? inhibitors have been reported in the treatment of patients with psoriasis. It is not known whether TNF-? inhibitors reveal underlying neurological disorders in patients with psoriasis. The aim of this study was to investigate whether there is an association between psoriasis and MS or peripheral neuropathy.Methods: In this study, 50 psoriasis patients and 25 healthy controls were enrolled. Neurological examination and needle electromyography test were performed. Serum levels of matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9), S-100 calcium-binding protein (S100B) and neuron specific enolase (NSE), which are involved in neuroinflammatory process, were measured. Results: Serum MMP-9 levels were higher in psoriasis patients compared to healthy controls. Serum MMP-2 and NSE levels were decreased in psoriasis patients compared to healthy controls. There was no significant difference in S100B levels between two groups. All neurophysiological parameters in each individual patient and control were found to be within normal limits and there was no difference between groups. Conclusion: NSE and MMP-9 might play role in the occurrence of MS in psoriasis patients. Especially, we are in the opinion that it might be useful to measure the serum levels of these markers before the administration of TNF-? inhibitors in psoriasis patients with family history of MS.
Açıklama
Anahtar Kelimeler
Psoriasis, Matriks metalloproteinaz 2, Matriks metalloproteinaz 9, S-100 kalsiyum-bağlayıcı protein beta alt birimi, Nöron spesifik enolaz, Elektromiyografi, Matrix metalloproteinase 2, Matrix metalloproteinase 9, S-100 calciumbinding protein beta subunit, Neuron specific enolase, Electromyography
Kaynak
Türk Dermatoloji Dergisi
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
10
Sayı
2
Künye
Güney, F., Tol, H., Balevi, A., Özdemir, M., Okudan, N., Belviranlı, M., Şahin, K. T. (2016). Psoriasisli hastalarda serum nöroinflamatuvar belirteç seviyeleri ve geniş çaplı periferik sinir lifi fonksiyonlarının değerlendirilmesi. Türk Dermatoloji Dergisi, 10, 2, 54-58.
