In Vivo Effects of Naringenin and Lead on Rat Erythrocyte Carbonic Anhydrase Enzyme
Yükleniyor...
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Karbonik anhidraz (CA) enzimi CO2'nin su ile tersinir reaksiyonunu katalizler ve sistemik asit baz dengesi, solunum gibi metabolik açıdan oldukça önemli olaylarda görev alır. Bu çalışmada canlıların farklı yollarla maruz kaldığı bir ağır metal olan kurşun ile bir flavanon olan naringeninin enzim üzerine in vivo etkisi araştırıldı.Gereç ve Yöntemler: Bu amaçla, dört farklı sıçan grubu oluşturuldu ve bunlardan biri kontrol grubu olarak belirlendi. Diğer üç gruba ise kurşun, naringenin ve kurşunnaringenin maddeleri verildi ve eritrositlerdeki CA enzim aktivitesindeki değişimler incelendi. Bulgular: Araştırma bulguları kontrol grubundaki enzim aktivitesinin diğer gruplardan daha fazla olduğunu gösterdi. Kurşun grubu en düşük inhibisyon etkisini gösterirken, narigenin grubu en yüksek inhibisyon etkisini gösterdi.Sonuç: Bu nedenle naringeninin CA enzimi için kuvvetli bir inhibitör olduğu söylenebilir.
Objectives: Carbonic anhydrase (CA) enzyme catalyses the reversible reactions of CO2 with water and takes part in metabolically important events such as systemic acid-base regulation and respiration. In this study, in vivo effects of lead, which is a heavy metal and to which living beings are exposed by different ways, with naringenin, a flavanone, were investigated. Materials and Methods: For this purpose, four different rat groups were established and one of them was chosen as the control group. The other three groups were given lead, naringenin and leadnaringenin substances to analyze the changes in the CA enzyme of rat erythrocytes. Results:The research findings showed that the enzyme activity in the control group was higher than that in the other groups. The naringenin group showed the highest inhibition effect, while the lead group showed the lowest inhibition. Conclusion:Therefore, it can be said that naringenin is a strong inhibitor of the CA enzyme.
Objectives: Carbonic anhydrase (CA) enzyme catalyses the reversible reactions of CO2 with water and takes part in metabolically important events such as systemic acid-base regulation and respiration. In this study, in vivo effects of lead, which is a heavy metal and to which living beings are exposed by different ways, with naringenin, a flavanone, were investigated. Materials and Methods: For this purpose, four different rat groups were established and one of them was chosen as the control group. The other three groups were given lead, naringenin and leadnaringenin substances to analyze the changes in the CA enzyme of rat erythrocytes. Results:The research findings showed that the enzyme activity in the control group was higher than that in the other groups. The naringenin group showed the highest inhibition effect, while the lead group showed the lowest inhibition. Conclusion:Therefore, it can be said that naringenin is a strong inhibitor of the CA enzyme.
Açıklama
Anahtar Kelimeler
Carbonic anhydrase, Inhibition, Lead, Naringenin, Karbonik anhidraz, İnhibisyon, Kurşun, Naringenin
Kaynak
Turkish Journal of Pharmaceutical Sciences
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
14
Sayı
1
Künye
Şahin, Z., Kuzu, M., Özkaya, A., Dağ, Ü, Çomaklı, V., Demirdağ, R. (2017). In vivo effects of naringenin and lead on rat erythrocyte carbonic anhydrase enzyme. Turkish Journal of Pharmaceutical Sciences, 14, 1, 9-12.
