Association of Severity of Coronary Lesion with Markers of Acute Infection and Inflammation in Patients with Acute Coronary Syndrome

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dc.authoridSedat Koçak: 0000-0001-8265-9615
dc.authoridZerrin Defne Dündar: 0000-0001-6431-5800
dc.authoridRecep Keşli: 0000-0002-2622-0760
dc.contributor.authorKoçak, Sedat
dc.contributor.authorDündar, Zerrin Defne
dc.contributor.authorHarmankaya, Atıf
dc.contributor.authorErdemir, Esma
dc.contributor.authorKeşli, Recep
dc.contributor.authorAlibasic, Hayrudin
dc.date.accessioned2020-01-18T21:02:50Z
dc.date.available2020-01-18T21:02:50Z
dc.date.issued2016
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Acil Tıp Anabilim Dalıen_US
dc.description.abstractAim: Inflammation and some infectious agents play a key role in acute coronary syndrome (ACS) caused by atherosclerosis. The purpose of this study was to assess the effects of inflammatory markers and the positivity of Chlamydia pneumoniae (CP), Helicobacter pylori (HP), and Cytomegalovirus (CMV) on the level of atherosclerosis in patients with ACS. Materials and Methods: Patients (57) that were referred to the emergency unit with classic angina symptoms or angina equivalent symptoms and were determined to have critical lesions in the coronary angiography (<70% stenosis, coronary artery disease (CAD) severity assessed by the Gensini score) were compared with 27 ACS patients who had no critical lesions in terms of procalcitonin (PCT), tumor necrosis factor-alpha (TNF-?), interleukin-2 receptor (IL2r), interleukin-6 (IL-6), and interleukin-10 (IL-10) levels and positivity of CP, HP, and CMV. Also, the two groups of ACS patients were compared in terms of cytokine levels measured at hours 0 and 48. Results: No significant association was found between the degree of the coronary lesion and the inflammatory and infectious agents. However, in patients with critical coronary lesions, as markers of inflammatory agents, the levels of IL-6 were significantly lower and levels of IL-10 were significantly higher (p>0.001 and p0.030, respectively) at hour 48 than originally found at hour 0. Conclusion: There is no association between the severity of coronary lesions and cytokine levels and positivity of infectious agents in ACS since the levels of proinflammatory cytokines in ACS are higher than those in atherosclerosis. The changes in cytokine levels at hour 48 were found to be significant.en_US
dc.identifier.citationKoçak, S., Dündar, Z. D., Harmankaya, A., Erdemir, E., Keşli, R., Alibasic, H. (2016). Association of severity of coronary lesion with markers of acute ınfection and inflammation in patients with acute coronary syndrome. Eurasian Journal of Emergency Medicine, 15, 4, 157-162.
dc.identifier.doi10.5152/eajem.2016.79188en_US
dc.identifier.endpage162en_US
dc.identifier.issn2149-5807en_US
dc.identifier.issn2149-6048en_US
dc.identifier.issue4en_US
dc.identifier.startpage157en_US
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TWpFMk9UUXhNUT09/association-of-severity-of-coronary-lesion-with-markers-of-acute-infection-and-inflammation-in-patients-with-acute-coronary-syndrome
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1303
dc.identifier.volume15en_US
dc.identifier.wosWOS:000391005500001en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.relation.ispartofEurasian Journal of Emergency Medicineen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCoronary lesionen_US
dc.subjectBiomarkersen_US
dc.subjectInfectionen_US
dc.subjectInflammationen_US
dc.subjectAcute coronary syndromeen_US
dc.titleAssociation of Severity of Coronary Lesion with Markers of Acute Infection and Inflammation in Patients with Acute Coronary Syndromeen_US
dc.typeArticleen_US

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