Preterm Erken Membran Rüptüründe Crp-Albumin Oranı Ve Nötrofil-Lenfosit Oranının Prediktif Değeri
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Tarih
2021
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Yayıncı
Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Bu çalışmada CAO (CRP-albümin oranı), NLO (nötrofil lenfosit oranı), PLO (platelet lenfosit oranı) ile PPROM ilişkisini araştırmayı amaçladık. Gereç ve Yöntem: Bu çalışma 01.01.2021-01.07.2021 tarihleri arasında Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi Kadın Hastalıkları ve Doğum Kliniği’ne poliklinik veya acil servisten su gelişi şikâyeti ile başvurup 24-37. gebelik haftaları PPROM tanısı konularak doğum yapan ve PPROM olmaksızın spontan erken doğum yapan ek hastalık ve kanama diyatezi bulunmayan ek ilaç kullanımı olmayan olgular dahil edilmiştir. Demografik veriler, tam kan sayım sonuçları, biyokimya ve yenidoğan sonuçları kaydedildi ve karşılaştırıldı. Bulgular: Gruplar arasında demografik özellikler açısından benzer sonuçlara ulaşılmıştır. Grupların lökosit, nötrofil ve bazofil sayılarında; MPV ve PDW sonuçları arasında istatistiksel anlamlı fark olduğu bulunmuştur (p<0.001; p:0.002). CRP değerleri tek başına anlamlı farklı bulunmuşken (p<0.001) albümin değerlerinde (p:0.069) tek başına anlamlı farklılık bulunmamıştır. CRP/Albümin oranı istatistiksel olarak anlamlı bulunmuş (p<0.001) ve PPROM'u teşhis etme yeteneği, ROC eğrisi analizi kullanılarak değerlendirildiğinde AUC 0,734'dür (p<0,001) (Şekil 4). CRP/Albümin oranının duyarlılığı ve özgüllüğü 0.1433'lük bir eşikte sırasıyla %64,81 ve %73,97 olmuştur. >0.1433 olan CRP/Albümin oranı değerleri PPROM riskinin artmasıyla önemli ölçüde ilişkili bulunmuştur. İki grup neonatal sonuçları karşılaştırıldığında sepsis ve yenidoğan yoğun bakım ünitesi ihtiyacı PPROM grubunda daha sık bulunmuştur (p:0.028 ve p:0.024). Sonuç: Bizim çalışmamızda CAO ve NLO PPROM ile ilişkili bulunmuş, literatürün aksine PLO ile ilişki bulunamamıştır.
In this study, we aimed to investigate the relationship between CAR (CRP-albumin ratio), NLR (neutrophil lymphocyte ratio), PLR (platelet lymphocyte ratio) and PPROM. Method: This study was carried out between 01.01.2021 and 01.07.2021, who applied to the Necmettin Erbakan University Meram Medical Faculty Gynecology and Obstetrics Clinic with the complaint of water coming from the outpatient clinic or emergency service and gave birth with the diagnosis of Premature Preterm Rupture Of Membranes at 24-37 weeks of gestation. Cases with spontaneous preterm delivery without Rupture Of Membranes, without comorbidity and bleeding diathesis, and without the use of additional medication were included. Demographic data, complete blood count results, biochemistry and newborn results were recorded and compared. Results: Similar results were obtained between the groups in terms of demographic characteristics. In the leukocyte, neutrophil and basophil counts of the groups; A statistically significant difference was found between MPV and PDW results (p<0.001; p:0.002). While CRP values alone were found to be significantly different (p<0.001), no significant difference was found alone in albumin values (p:0.069). The CRP/Albumin ratio was statistically significant (p<0.001) and the ability to diagnose PPROM was AUC 0.734 (p<0.001) when evaluated using ROC curve analysis (Fig. 4). The sensitivity and specificity of the CRP/Albumin ratio were 64.81% and 73.97%, respectively, at a threshold of 0.1433. CRP/Albumin ratio values >0.1433 were significantly associated with an increased risk of PPROM. When the neonatal outcomes of the two groups were compared, sepsis and neonatal intensive care unit need were found to be more common in the PPROM group (p:0.028 and p:0.024). Conclusion: In our study, CAR and NLR were found to be associated with PPROM, unlike the literature, no relationship was found with PLR.
In this study, we aimed to investigate the relationship between CAR (CRP-albumin ratio), NLR (neutrophil lymphocyte ratio), PLR (platelet lymphocyte ratio) and PPROM. Method: This study was carried out between 01.01.2021 and 01.07.2021, who applied to the Necmettin Erbakan University Meram Medical Faculty Gynecology and Obstetrics Clinic with the complaint of water coming from the outpatient clinic or emergency service and gave birth with the diagnosis of Premature Preterm Rupture Of Membranes at 24-37 weeks of gestation. Cases with spontaneous preterm delivery without Rupture Of Membranes, without comorbidity and bleeding diathesis, and without the use of additional medication were included. Demographic data, complete blood count results, biochemistry and newborn results were recorded and compared. Results: Similar results were obtained between the groups in terms of demographic characteristics. In the leukocyte, neutrophil and basophil counts of the groups; A statistically significant difference was found between MPV and PDW results (p<0.001; p:0.002). While CRP values alone were found to be significantly different (p<0.001), no significant difference was found alone in albumin values (p:0.069). The CRP/Albumin ratio was statistically significant (p<0.001) and the ability to diagnose PPROM was AUC 0.734 (p<0.001) when evaluated using ROC curve analysis (Fig. 4). The sensitivity and specificity of the CRP/Albumin ratio were 64.81% and 73.97%, respectively, at a threshold of 0.1433. CRP/Albumin ratio values >0.1433 were significantly associated with an increased risk of PPROM. When the neonatal outcomes of the two groups were compared, sepsis and neonatal intensive care unit need were found to be more common in the PPROM group (p:0.028 and p:0.024). Conclusion: In our study, CAR and NLR were found to be associated with PPROM, unlike the literature, no relationship was found with PLR.
Açıklama
Anahtar Kelimeler
Albümin, CAO, CRP, CRP/Albümin oranı, Albumin, CAR, CRP, CRP/Albumin ratio
Kaynak
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Gündoğan, K. M. (2021). Preterm Erken Membran Rüptüründe Crp-Albumin Oranı ve Nötrofil-Lenfosit Oranının Prediktif Değeri. (Yayınlanmamış tıpta uzmanlık tezi) Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi Cerrahi Tıp Bilimleri Bölümü Kadın Hastalıkları ve Doğum Anabilim Dalı, Konya.
