Covıd-19 tanılı kritik hastalarda, platelet lenfositoranı, monosit lenfosit oranı ve diğer bazıhematolojik değerlerin prognoza etkisi
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Dosyalar
Tarih
2021
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Giriş ve amaç: 2019 Yeni Koronavirus Hastalığı Çin'in Wuhan şehrinde başlayıp 2020
yılında tüm dünyaya yayılarak pandemiye neden olmuştur. Milyonlarca insanın enfekte
olduğu ve yüksek mortaliteye sahip bu hastalıkta mortalite öngörüsü ve kritik hastaların ayırt
edilmesi büyük önem taşımaktadır. Acil Servis’e başvuran, COVID-19 tanısı olan hastaların
ciddiyetinin erken dönemde belirlenmesi, tedavi sürecine erken başlanması faydalı olacaktır.
Bu çalışmada, yoğun bakım ünitesi (YBÜ)’ne COVID-19 tanısı ile yatırılan hastaların
platelet lenfosit oranı (PLR) ve monosit lenfosit oranları (MLR) YBÜ yatış ihtiyacı olmayan
hastaların değerleri ile karşılaştırılması ve prognozu öngörme başarısı amaçlanmıştır. Aynı
zamanda bu hastalardan vefat eden ve otucuncu günde sağ kalanlar arasında PLR ve MLR
değerlerinin mortalite ile ilişkisi incelenmiştir.
Yöntem: Acil Servis’e COVID-19 öntanısı ile başvurup yoğun bakım ünitesine yatırılan
hastalar ile YBÜ yatış ihtiyacı olmayan hastalar (kontrol grubu) çalışmaya dahil edildi. 18
yaş üstü ve PCR + hastalar çalışmaya alındı. Bu hastaların yaş, cinsiyet, başvuru şikayetleri,
komorbiditeleri, vital değerleri, laboratuvar değerleri, BT görüntülemeleri, aldıkları oksijen
tedavileri, hastane yatış süreleri ve hastane sonlanım bilgileri kaydedildi. Hasta verileri SPSS
25.0 programına girildi, daha sonra hasta veri analizi yapıldı. Kategorik değişkenler n (%),
normal dağılıma uymayan numerik değişkenler medyan (çeyrekler açıklığı) şeklinde ifade
edildi.
Bulgular: Bu çalışmada toplam, hasta grubu (267) ve kontrol grubu (272) olmak üzere 539
hasta değerlendirildi. YBÜ grubunda hastaların ortanca yaşı 72 yıl, kontrol grubunda 66 yıl
idi ve hastaların 287 (%53)’si erkekti. YBÜ grubunda PLR ve MLR değerleri kontrol
grubuna kıyasla daha yüksekti ve sonuçlar istatistiksel olarak anlamlı idi (p<0,001). Kritik
hastalarda yaşayan ve vefat eden hastalar arasında PLR ve MLR değerleri anlamlı değildi (p
değerleri sırasıyla; p=0,166, p=0,694).
Sonuç: COVID-19 tanısı ile yatırılan kritik hastalar incelendiğinde literatüre benzer şekilde
erkek hastaların daha fazla etkilendiği, YBÜ’ye yatan hastaların yaş ve mortalitesinin daha
Introduction and purpose: The 2019 New Coronavirus Disease started in Wuhan, China, and spread to the whole world in 2020, causing a pandemic. In this disease, in which millions of people are infected and has a high mortality, predicting mortality and distinguishing critically ill patients are of great importance. It would be beneficial to determine the severity of patients with a diagnosis of COVID-19 who applied to the Emergency Service and to start the treatment process early. In this study, the platelet lymphocyte ratio (PLR) and monocyte lymphocyte ratio (MLR) of patients hospitalized the intensive care unit (ICU) with the diagnosis of COVID-19 was compared with the values of patients who do not need ICU admission, and the success of predicting prognosis was examined. At the same time, the relationship between PLR and MLR values and mortality among those survived on the thirtieth day and who died was examined. Method: Applied to the Emergency Department with a pre-diagnosis of COVID-19, patients admitted to the intensive care unit and patients who did not need ICU admission (control group) were included. Patients over 18 years of age and PCR + were included in the study. Age, gender, admission complaints, comorbidities, vital values, laboratory values, CT scans, oxygen treatments they received, length of hospital stay and hospital outcome information of these patients were recorded. Patient data were entered into the SPSS 25.0 program, then patient data analysis was performed. Categorical variables were expressed as n (%), and numeric variables that did not fit the normal distribution were expressed as median (quartile range). Findings: In this study, a total of 539 patients, including the patient group (267) and the control group (272), were evaluated. The median age of the patients in the ICU group was 72 years, in the control group 66 years, and 287 (53%) of the patients were male. PLR and MLR values were higher in the ICU group compared to the control group, and the results were statistically significant (p<0.001). PLR and MLR values were not significant between living and deceased patients in critically ill patients (p values; p=0.166, p=0.694, respectively).
Introduction and purpose: The 2019 New Coronavirus Disease started in Wuhan, China, and spread to the whole world in 2020, causing a pandemic. In this disease, in which millions of people are infected and has a high mortality, predicting mortality and distinguishing critically ill patients are of great importance. It would be beneficial to determine the severity of patients with a diagnosis of COVID-19 who applied to the Emergency Service and to start the treatment process early. In this study, the platelet lymphocyte ratio (PLR) and monocyte lymphocyte ratio (MLR) of patients hospitalized the intensive care unit (ICU) with the diagnosis of COVID-19 was compared with the values of patients who do not need ICU admission, and the success of predicting prognosis was examined. At the same time, the relationship between PLR and MLR values and mortality among those survived on the thirtieth day and who died was examined. Method: Applied to the Emergency Department with a pre-diagnosis of COVID-19, patients admitted to the intensive care unit and patients who did not need ICU admission (control group) were included. Patients over 18 years of age and PCR + were included in the study. Age, gender, admission complaints, comorbidities, vital values, laboratory values, CT scans, oxygen treatments they received, length of hospital stay and hospital outcome information of these patients were recorded. Patient data were entered into the SPSS 25.0 program, then patient data analysis was performed. Categorical variables were expressed as n (%), and numeric variables that did not fit the normal distribution were expressed as median (quartile range). Findings: In this study, a total of 539 patients, including the patient group (267) and the control group (272), were evaluated. The median age of the patients in the ICU group was 72 years, in the control group 66 years, and 287 (53%) of the patients were male. PLR and MLR values were higher in the ICU group compared to the control group, and the results were statistically significant (p<0.001). PLR and MLR values were not significant between living and deceased patients in critically ill patients (p values; p=0.166, p=0.694, respectively).
Açıklama
Anahtar Kelimeler
COVID-19, Coronavirus, Pnömoni, Mortalite, COVID-19, Coronavirus, Pneumonia, Mortality
Kaynak
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Dede, S, (2021). Covıd-19 tanılı kritik hastalarda, platelet lenfositoranı, monosit lenfosit oranı ve diğer bazıhematolojik değerlerin prognoza etkisi. (Yayınlanmamış tıpta uzmanlık tezi) Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi Dahili Tıp Bilimleri Bölümü Acil Tıp Anabilim Dalı, Konya.
