An update on the multimodality of localized rectal cancer
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
New strategies have reduced the local recurrence (LR) rate and extended the duration of overall survival (OS) in patients with localized rectal cancer (RC) in recent decades. The mainstay of curative treatment remains radical surgery; however, downsizing the tumor by neo-adjuvant chemo-radiotherapy and adjuvant cytotoxic therapy for systemic disease has shown significant additional benefit. The standardization of total mesorectal excision (TME), radiation treatment (RT) dose and fractionation, and optimal timing and sequencing of treatment modalities with the use of prolonged administration of fluoropyrimidine concurrent with RT have significantly decreased the rates of LR in locally advanced rectal cancer (LARC) patients. This review focuses on the optimization of multi-modality therapies in patients with localized RC. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
Rectal Cancer, Locally Advanced, Neo-Adjuvant, Surgery, Chemo-Radiotherapy
Kaynak
Critical Reviews In Oncology Hematology
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
108
