An update on the multimodality of localized rectal cancer

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dc.contributor.authorArtac, Mehmet
dc.contributor.authorKorkmaz, Levent
dc.contributor.authorEl-Rayes, Bassel
dc.contributor.authorPhilip, Philip A.
dc.date.accessioned2024-02-23T14:02:39Z
dc.date.available2024-02-23T14:02:39Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractNew strategies have reduced the local recurrence (LR) rate and extended the duration of overall survival (OS) in patients with localized rectal cancer (RC) in recent decades. The mainstay of curative treatment remains radical surgery; however, downsizing the tumor by neo-adjuvant chemo-radiotherapy and adjuvant cytotoxic therapy for systemic disease has shown significant additional benefit. The standardization of total mesorectal excision (TME), radiation treatment (RT) dose and fractionation, and optimal timing and sequencing of treatment modalities with the use of prolonged administration of fluoropyrimidine concurrent with RT have significantly decreased the rates of LR in locally advanced rectal cancer (LARC) patients. This review focuses on the optimization of multi-modality therapies in patients with localized RC. (C) 2016 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.critrevonc.2016.10.004
dc.identifier.endpage32en_US
dc.identifier.issn1040-8428
dc.identifier.issn1879-0461
dc.identifier.pmid27931837en_US
dc.identifier.scopus2-s2.0-85006415517en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage23en_US
dc.identifier.urihttps://doi.org/10.1016/j.critrevonc.2016.10.004
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11792
dc.identifier.volume108en_US
dc.identifier.wosWOS:000390719700003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofCritical Reviews In Oncology Hematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRectal Canceren_US
dc.subjectLocally Advanceden_US
dc.subjectNeo-Adjuvanten_US
dc.subjectSurgeryen_US
dc.subjectChemo-Radiotherapyen_US
dc.titleAn update on the multimodality of localized rectal canceren_US
dc.typeReview Articleen_US

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