Oxidant and antioxidant parameters in prediabetes and diabetes

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dc.contributor.authorErdem, Said Sami
dc.contributor.authorToker, Aysun
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorCicekler, Humeyra
dc.contributor.authorGonulalan, Gulsum
dc.contributor.authorAbdulhalikov, Turyan
dc.contributor.authorYerlikaya, Fatma Humeyra
dc.date.accessioned2024-02-23T14:00:08Z
dc.date.available2024-02-23T14:00:08Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractThe aim of our study was to evaluate serum paraoxonase (PON1), total antioxidant status (TAS), total oxidant status (TOS), and ischemia-modified albumin (IMA) levels in patients with prediabetes, diabetes, and in healthy control subjects. The subjects were aged between 20 and 60 years. Forty diabetic subjects (mean age 46.6 +/- 9.7 years), 39 prediabetic subjects (mean age 44.0 +/- 9.3 years) and 24 healthy control subjects (mean age 43.7 +/- 9.7 years). Lipid profile, PON1, TAS, TOS and IMA levels were measured. The serum TOS and IMA levels in diabetes were significantly higher than those of the control subjects (P=0.024 and P=0.012, respectively), while the serum PON1 levels of the diabetes patients were significantly lower than those of the control subjects (P=0.039). The serum TOS levels of the diabetes patients were significantly higher than those of the subjects with prediabetes (P=0.013). There were no significant differences between the serum IMA and PON1 levels of the prediabetes and diabetes groups (P=0.075 and P=0.110, respectively). The serum TAS levels of the three groups were similar. The present study demonstrated that in diabetes there is greater oxidative stress. Patients with type 2 diabetes had higher TOS and IMA levels, but lower PON1 values, than controls. There were no differences in oxidative stress markers between prediabetic patients and healthy subjects.en_US
dc.identifier.doi10.1007/s13410-013-0185-4
dc.identifier.endpageS470en_US
dc.identifier.issn0973-3930
dc.identifier.issn1998-3832
dc.identifier.scopus2-s2.0-84953250730en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpageS465en_US
dc.identifier.urihttps://doi.org/10.1007/s13410-013-0185-4
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11456
dc.identifier.volume35en_US
dc.identifier.wosWOS:000411020700030en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Indiaen_US
dc.relation.ispartofInternational Journal Of Diabetes In Developing Countriesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTotal Antioxidant Statusen_US
dc.subjectTotal Oxidant Statusen_US
dc.subjectIschemia-Modified Albuminen_US
dc.subjectParaoxonaseen_US
dc.subjectPrediabetesen_US
dc.titleOxidant and antioxidant parameters in prediabetes and diabetesen_US
dc.typeArticleen_US

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