May Monocyte/HDL Cholesterol Ratio (MHR) and Neutrophil/Lymphocyte Ratio (NLR) Be an Indicator of Inflammation and Oxidative Stress in Patients with Keratoconus?
Küçük Resim Yok
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: To evaluate monocyte/high-density lipoprotein cholesterol ratio (MHR) and neutrophil/lymphocyte ratio (NLR) in patients with keratoconus (KC). Methods: Thirty-one patients with KC (group 1) and 31 healthy control subjects (group 2) were included in the study. All participants' ocular examination findings, clinical and laboratory parameters were obtained from file records and laboratory archives. Results: When group 1 was compared with group 2, MHR (13.7 +/- 5.0 vs. 9.1 +/- 3.7; p < .001) and NLR (2.3 +/- 0.8 vs. 1.7 +/- 0.6; p < .001) were statistically significantly higher in group 1. Optimal MHR cutoff value for KC was calculated as 10.2 with 77.4% sensitivity and 64.5% specificity, and optimal NLR cut-off value for KC was found as 1.9 with 71.4% sensitivity and 55% specificity. Conclusion: MHR and NLR values recognized as indicators of oxidative stress and systemic inflammation were significantly higher in patients with KC compared to the control group.
Açıklama
Anahtar Kelimeler
Inflammation, Keratoconus, Monocyte, Hdl Ratio, Neutrophil, Lymphocyte Ratio, Oxidative Stress
Kaynak
Ocular Immunology And Inflammation
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
28
Sayı
4
