Determination of carcinoembryonic antigen (CEA) by surface plasmon resonance-enhanced total internal reflection ellipsometry (SPRe-TIRE)

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dc.contributor.authorErkal-Aytemur, Asli
dc.contributor.authorSahin, Samet
dc.contributor.authorUstundag, Zafer
dc.contributor.authorMulazimoglu, Ibrahim Ender
dc.contributor.authorCaglayan, Mustafa Oguzhan
dc.date.accessioned2024-02-23T14:20:30Z
dc.date.available2024-02-23T14:20:30Z
dc.date.issued2024
dc.departmentNEÜen_US
dc.description.abstractA surface plasmon resonance-enhanced total internal reflection ellipsometric (SPRe-TIRE) aptasensor is reported for the determination of the carcinoembryonic antigen (CEA). A gold nanofilm-coated SF10 glass slide was modified with electrochemical diazonium salt reduction and gold nanoparticles (AuNPs) to form a sensor. Next, a specific aptamer for CEA was immobilized on the AuNPs via self-assembly. The platform was characterized by X-ray photoelectron spectroscopy, ellipsometry, and cyclic voltammetry for each step of the preparation of the sensor. CEA aptamers with different affinities were used. SPRe-TIRE employed total internal reflection geometry and AuNPs to enhance plasmon resonance for the sensitive and selective determination of CEA in human serum. The working range of the aptasensor was from 0.01 to 500 ng/mL with an optimum detection limit of 0.1 pg/mL.en_US
dc.description.sponsorshipTUBITAK (Scientific and Technological Research Council of Turkey) [122Z678]en_US
dc.description.sponsorshipThis work was supported by TUBITAK (Scientific and Technological Research Council of Turkey) by project number 122Z678.en_US
dc.identifier.doi10.1080/10739149.2023.2242921
dc.identifier.endpage219en_US
dc.identifier.issn1073-9149
dc.identifier.issn1525-6030
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85166968824en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage203en_US
dc.identifier.urihttps://doi.org/10.1080/10739149.2023.2242921
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13178
dc.identifier.volume52en_US
dc.identifier.wosWOS:001042461500001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofInstrumentation Science & Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCarcinoembryonic Antigen (Cea)en_US
dc.subjectSurface Plasmon Resonance-Enhanced Total Internal Reflection Ellipsometry (Spre-Tire)en_US
dc.subjectAptasensoren_US
dc.subjectCyclic Voltammetry (Cv)en_US
dc.titleDetermination of carcinoembryonic antigen (CEA) by surface plasmon resonance-enhanced total internal reflection ellipsometry (SPRe-TIRE)en_US
dc.typeArticleen_US

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