Statik ve dinamik pupillometri parametrelerinin yaş, aksiyel uzunluk ve refraktif değer ile ilişkilerinin incelenmesi
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Tarih
2022
Yazarlar
Dergi Başlığı
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Cilt Başlığı
Yayıncı
Necmettin Erbakan Üniversitesi Meram Tıp Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Kliniğimize başvuran olgularda statik ve dinamik pupillometri ölçümlerinin
değerlendirilmesi ve elde edilen parametrelerin yaş, aksiyel uzunluk, refraktif değer gibi
değişkenler ile ilişkilerinin incelenmesi amaçlandı.
Yöntem:
Çalışmaya Temmuz 2021 Ocak 2022 tarihleri arasında Necmettin Erbakan
Üniversitesi Meram Tıp Fakültesi Hastanesi Göz Hastalıkları Kliniği’ne başvuran, 18 65
yaş aral ığında 108 olgu dahil edildi. Pupilla fonksiyonlarını etkileyebilecek diyabet,
nörolojik hastalık, travma öyküsü, glokom, retina ve optik sinir patolojileri olan olgular ile
otonom sinir sistemi fonksiyonlarını etkileyebilecek ilaç kullanımı olan olgular ç alışma
dışı bırakıldı. Tüm olguların tam oftalmolojik muayenelerinin ardından aksiyel uzunluk
ölçümü (IOLMaster®; Carl Zeiss Meditec, Almanya) ve pupillometrik incelemeleri
yapıldı. Statik ve dinamik pupillometri ölçümleri bilgisayarlı otomatize pupillomet ri cihazı
(MonPackOne®; Metrovision, Fransa) ile değerlendirildi. Verilerin istatsitiksel analizi
SAS University Edition 9.4 programı kullanılarak yapıldı ve anlamlılık düzeyi P<0.05
olarak kabul edildi.
Bulgular:
Çalışmaya dahil edilen 108 olgunun (63 k adın, 45 erkek) yaş ortalaması 39.0 ±
13.3 yıl idi. Her iki cinsiyet arasında statik pupillometri parametrelerinin hiçbirinde
istatistiksel olarak anlamlı fark izlenmedi. Çoklu regresyon analizlerinde cinsiyetin
başlangıç pupil çapı (kadın olgularda daha y üksek, P=0.038), pupil kontraksiyon süresi
(kadın olgularda daha uzun, P=0.005), dilatasyon latansı (kadın olgularda daha uzun,
P=0.007) ve dilatasyon süresi (kadın olgularda daha kısa, P=0.011) üzerinde istatistiksel
olarak anlamlı etki oluşturduğu, diğer parametreler üzerinde etkisinin olmadığı görüldü.
Olguların yaşı ile skotopik, mezopik, düşük fotopik ve yüksek fotopik ortamda elde edilen
pupil çapları arasında negatif korelasyon saptandı (P<0.001). Dinamik pupillometri
parametreleri incelendiğinde ise yaş ile başlangıç pupil çapı (t= 8.68; P<0.001), pupil
v
kontraksiyon amplitüdü (t=
kontraksiyon amplitüdü (t=--6.53; P<0.001), kontraksiyon latansı (t=2.14; P=0.035), 6.53; P<0.001), kontraksiyon latansı (t=2.14; P=0.035), kontraksiyon hızı (t=kontraksiyon hızı (t=--5.22; P<0.001), dilatasyon latansı (t=2.35; P=0.021) ve dilatasyon 5.22; P<0.001), dilatasyon latansı (t=2.35; P=0.021) ve dilatasyon hızı (t=hızı (t=--4.26; P<0.001) aras4.26; P<0.001) arasında anlamlı ilişki olduğu izlendi. Aksiyel uzunluğun skotopik ında anlamlı ilişki olduğu izlendi. Aksiyel uzunluğun skotopik (t=3.08; P=0.003) ve yüksek fotopik pupil çapı (t=2.12; P=0.036) üzerinde anlamlı (t=3.08; P=0.003) ve yüksek fotopik pupil çapı (t=2.12; P=0.036) üzerinde anlamlı etkisinin olduğu; dinamik pupillometri parametrelerinden ise başlangıç pupil çapı (t=2.89; etkisinin olduğu; dinamik pupillometri parametrelerinden ise başlangıç pupil çapı (t=2.89; P=0.005), pupil kontP=0.005), pupil kontraksiyon süresi (t=2.40; P=0.019) ve dilatasyon latansı (t=2.86; raksiyon süresi (t=2.40; P=0.019) ve dilatasyon latansı (t=2.86; P=0.005) ile korelasyon gösterdiği saptandı. Sferik eşdeğerin ise pupillometri P=0.005) ile korelasyon gösterdiği saptandı. Sferik eşdeğerin ise pupillometri parametrelerinin hiçbiri üzerinde anlamlı etkilerinin olmadığı görüldü (P>0.05).parametrelerinin hiçbiri üzerinde anlamlı etkilerinin olmadığı görüldü (P>0.05).
Sonuç:
Sonuç: Bu çalışmada yaş ve aksiBu çalışmada yaş ve aksiyel uzunluk değerlerinin statik ve dinamik pupillometri yel uzunluk değerlerinin statik ve dinamik pupillometri parametreleri üzerinde anlamlı etkilerinin olduğu, cinsiyetin yalnızca dinamik pupillometri parametreleri üzerinde anlamlı etkilerinin olduğu, cinsiyetin yalnızca dinamik pupillometri parametreleri üzerinde etkili olduğu, refraktif değerin ise pupillometri sonuçlarını parametreleri üzerinde etkili olduğu, refraktif değerin ise pupillometri sonuçlarını etkilemediği gösterilmietkilemediği gösterilmiştir. Çalışma sonuçlarının daha geniş serilerle desteklenmesi ştir. Çalışma sonuçlarının daha geniş serilerle desteklenmesi gerekmekle birlikte klinik araştırmalarda pupillometrik inceleme yapılırken olguların yaş, gerekmekle birlikte klinik araştırmalarda pupillometrik inceleme yapılırken olguların yaş, cinsiyet ve aksiyel uzunluk verilerinin dikkate alınması yerinde olacaktır.cinsiyet ve aksiyel uzunluk verilerinin dikkate alınması yerinde olacaktır.
: The aim of this study was to evaluate the static and dynamic pupillometry measurements of the participants and to examine the relationships between the obtained parameters and the variables such as age, axial length, and refractive error. Methods : A total of 1 08 subjects aged between 18 65 years who applied to the Ophthalmology Department of Necmettin Erbakan University Meram Medical Faculty Hospital between July 2021 and January 2022 were included in the study. Subjects with diabetes, neurological disorders, p revious history of trauma, glaucoma, retinal or optic nerve pathologies that may affect pupillary functions, and those receiving medications that may affect autonomic nervous system functions were excluded. Axial length measurement (IOLMaster®; Carl Zeiss Meditec, Germany) and pupillometric assessment were performed after a complete ophthalmologic examination in all subjects. Static and dynamic pupillary responses were evaluated with a computerized automated pupillometry device (MonPackOne®; Metrovision, Fr ance). SAS University Edition 9.4 program was used for statistical analysis and a P value of less than 0.05 was considered statistically significant. Results : The mean age of the total 108 participants (63 female, 45 male) was 39.0 ± 13.3 years. No statistically significant differences were observed in any of the static pupillometry parameters between the two genders. Multiple regression analyzes revealed that the gender factor had a statistically significant effect on initial pupil diameter (higher in female subjects, P=0.038), duration of contraction (longer in female subjects, P=0.005), latency of dilation (longer in female subjects, P=0.007) and duration of dilation (shorter in female subjects, P=0.011), while it did not have a significant effect on other parameters. The age of the subjects was inversely correlated with all static pupillometry parameters obtained at scotopic, mesopic, low photopic, and high photopic conditions (P<0.001). Assessment of the dynamic pupillary parameters revealed that age was significantly related with initial pupil diameter (t= 8.68; P<0.001), amplitude of pupil contraction (t= 6.53; vii P<0.001), latency of contraction (t=2.14; P=0.035), velocity of contraction (t= P<0.001), latency of contraction (t=2.14; P=0.035), velocity of contraction (t=--5.22; 5.22; P<0.001), latency of pupil dilation (t=2.35; P=0.02P<0.001), latency of pupil dilation (t=2.35; P=0.021), and velocity of dilation (t=1), and velocity of dilation (t=--4.26; 4.26; P<0.001). Axial length had significant effects on scotopic (t=3.08; P=0.003) and high P<0.001). Axial length had significant effects on scotopic (t=3.08; P=0.003) and high photopic pupil diameters (t=2.12; P=0.036), and was correlated with some of the dynamic photopic pupil diameters (t=2.12; P=0.036), and was correlated with some of the dynamic pupillary parameters including initial pupipupillary parameters including initial pupil diameter (t=2.89; P=0.005), duration of pupil l diameter (t=2.89; P=0.005), duration of pupil contraction (t=2.40; P=0.019) and latency of dilation (t=2.86; P=0.005). Spherical contraction (t=2.40; P=0.019) and latency of dilation (t=2.86; P=0.005). Spherical equivalent had no significant effect on any of the pupillometry parameters (P>0.05 for all).equivalent had no significant effect on any of the pupillometry parameters (P>0.05 for all). Conclusion Conclusion: This study demonstra: This study demonstrated that age and axial length had significant effects on ted that age and axial length had significant effects on static and dynamic pupillometry parameters, and gender was effective only on dynamic static and dynamic pupillometry parameters, and gender was effective only on dynamic pupillometry parameters while the refractive error did not affect the pupillary outcomes. pupillometry parameters while the refractive error did not affect the pupillary outcomes. Although the results of Although the results of this study needed to be supported by larger series, it would be this study needed to be supported by larger series, it would be appropriate to consider the age, gender and axial length of the subjects when performing appropriate to consider the age, gender and axial length of the subjects when performing pupillometric examination in clinical studies.pupillometric examination in clinical studies.
: The aim of this study was to evaluate the static and dynamic pupillometry measurements of the participants and to examine the relationships between the obtained parameters and the variables such as age, axial length, and refractive error. Methods : A total of 1 08 subjects aged between 18 65 years who applied to the Ophthalmology Department of Necmettin Erbakan University Meram Medical Faculty Hospital between July 2021 and January 2022 were included in the study. Subjects with diabetes, neurological disorders, p revious history of trauma, glaucoma, retinal or optic nerve pathologies that may affect pupillary functions, and those receiving medications that may affect autonomic nervous system functions were excluded. Axial length measurement (IOLMaster®; Carl Zeiss Meditec, Germany) and pupillometric assessment were performed after a complete ophthalmologic examination in all subjects. Static and dynamic pupillary responses were evaluated with a computerized automated pupillometry device (MonPackOne®; Metrovision, Fr ance). SAS University Edition 9.4 program was used for statistical analysis and a P value of less than 0.05 was considered statistically significant. Results : The mean age of the total 108 participants (63 female, 45 male) was 39.0 ± 13.3 years. No statistically significant differences were observed in any of the static pupillometry parameters between the two genders. Multiple regression analyzes revealed that the gender factor had a statistically significant effect on initial pupil diameter (higher in female subjects, P=0.038), duration of contraction (longer in female subjects, P=0.005), latency of dilation (longer in female subjects, P=0.007) and duration of dilation (shorter in female subjects, P=0.011), while it did not have a significant effect on other parameters. The age of the subjects was inversely correlated with all static pupillometry parameters obtained at scotopic, mesopic, low photopic, and high photopic conditions (P<0.001). Assessment of the dynamic pupillary parameters revealed that age was significantly related with initial pupil diameter (t= 8.68; P<0.001), amplitude of pupil contraction (t= 6.53; vii P<0.001), latency of contraction (t=2.14; P=0.035), velocity of contraction (t= P<0.001), latency of contraction (t=2.14; P=0.035), velocity of contraction (t=--5.22; 5.22; P<0.001), latency of pupil dilation (t=2.35; P=0.02P<0.001), latency of pupil dilation (t=2.35; P=0.021), and velocity of dilation (t=1), and velocity of dilation (t=--4.26; 4.26; P<0.001). Axial length had significant effects on scotopic (t=3.08; P=0.003) and high P<0.001). Axial length had significant effects on scotopic (t=3.08; P=0.003) and high photopic pupil diameters (t=2.12; P=0.036), and was correlated with some of the dynamic photopic pupil diameters (t=2.12; P=0.036), and was correlated with some of the dynamic pupillary parameters including initial pupipupillary parameters including initial pupil diameter (t=2.89; P=0.005), duration of pupil l diameter (t=2.89; P=0.005), duration of pupil contraction (t=2.40; P=0.019) and latency of dilation (t=2.86; P=0.005). Spherical contraction (t=2.40; P=0.019) and latency of dilation (t=2.86; P=0.005). Spherical equivalent had no significant effect on any of the pupillometry parameters (P>0.05 for all).equivalent had no significant effect on any of the pupillometry parameters (P>0.05 for all). Conclusion Conclusion: This study demonstra: This study demonstrated that age and axial length had significant effects on ted that age and axial length had significant effects on static and dynamic pupillometry parameters, and gender was effective only on dynamic static and dynamic pupillometry parameters, and gender was effective only on dynamic pupillometry parameters while the refractive error did not affect the pupillary outcomes. pupillometry parameters while the refractive error did not affect the pupillary outcomes. Although the results of Although the results of this study needed to be supported by larger series, it would be this study needed to be supported by larger series, it would be appropriate to consider the age, gender and axial length of the subjects when performing appropriate to consider the age, gender and axial length of the subjects when performing pupillometric examination in clinical studies.pupillometric examination in clinical studies.
Açıklama
Anahtar Kelimeler
Aksiyel uzunluk, Dinamik pupillometri, Pupilla, Sferik eşdeğer, Statik pupillometri, Axial length, dynamic pupillometry, Pupilla, Spherical equivalent, Static pupillometry
Kaynak
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Demirci, S. F. (2022). Statik ve dinamik pupillometri parametrelerinin yaş, aksiyel uzunluk ve refraktif değer ile ilişkilerinin incelenmesi. (Yayınlanmamış tıpta uzmanlık tezi) Necmettin Erbakan Üniversitesi, Meram Tıp Fakültesi Cerrahi Tıp Bilimleri Bölümü Göz Hastalıkları Anabilim Dalı, Konya.
