Bioactive constituents of Lathyrus czeczottianus and ethyl acetate and water extracts and their biological activities: An endemic plant to Turkey

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dc.contributor.authorCeylan, Ramazan
dc.contributor.authorZengin, Gokhan
dc.contributor.authorGuler, Gokalp Ozmen
dc.contributor.authorAktumsek, Abdurrahman
dc.date.accessioned2024-02-23T14:16:11Z
dc.date.available2024-02-23T14:16:11Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractLathyrus species are economically important as food, fodder, and folk medicine. The antioxidant properties (radical scavenging effectiveness, reducing power potentials, metal chelating ability, phosphomolydenum capacity) phytochemical characterization (phenolic composition), and enzyme inhibition abilities of the water and ethyl acetate extracts of Lathyrus czeczottianus (LC) were tested. The phenolic ingradients of LC extracts were evaluated by HPLC-DAD (High-performance liquid chromatography with diode array detector). Chlorogenic acid, epicatechin, and benzoic acid were found as main phenolic compounds in both extracts. Generally, the water extract revealed strong antioxidant potential. The antioxidant effectiveness could be explained by high total phenolic level in the extract. Regarding enzyme inhibitory results, the ethyl acetate extract indicated good inhibitory activities on cholinesterase (for AChE: Acetylccholinesterase 1.15 mg galathamine equivalents (GALAE/g extract) and for BChE: Butyrylcholinesterase 0.19 mg GALAE/g extrac), tyrosinase (54.48 mg kojic acid equivalents (KAE/g)), and alpha-amylase (0.34 mmol acarbose equivalents (ACEs/g)), while the water extract had just good inhibition on alpha-glucosidase (6.49 mmol ACEs/g). In conclusion, L. czeczottianus could be good valuable of bioactive molecules for pharmaceuticals, food and agriculture, and nutraceutical applications. (C) 2020 SAAB. Published by Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [113Z892]en_US
dc.description.sponsorshipThis study was supported by The Scientific and Technological Research Council of Turkey (TUBITAK) (Project Number: 113Z892).en_US
dc.identifier.doi10.1016/j.sajb.2020.11.023
dc.identifier.endpage311en_US
dc.identifier.issn0254-6299
dc.identifier.issn1727-9321
dc.identifier.scopus2-s2.0-85097474207en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage306en_US
dc.identifier.urihttps://doi.org/10.1016/j.sajb.2020.11.023
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12552
dc.identifier.volume143en_US
dc.identifier.wosWOS:000767313800005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofSouth African Journal Of Botanyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLathyrusen_US
dc.subjectAntioxidanten_US
dc.subjectHplcen_US
dc.subjectPhenolic Compoundsen_US
dc.subjectEnzyme Inhibitionen_US
dc.titleBioactive constituents of Lathyrus czeczottianus and ethyl acetate and water extracts and their biological activities: An endemic plant to Turkeyen_US
dc.typeArticleen_US

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