Diagnostic and Prognostic Significance of Neutrophil Gelatinase- Associated Lipocalin and Pentraxin-3 in Acute Coronary Syndrome

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dc.authorid0000-0002-7729-7557en_US
dc.authorid0000-0002-9420-6514en_US
dc.authorid0000-0001-6431-5800en_US
dc.authorid0000-0003-2669-0532en_US
dc.authorid0000-0001-8265-9615en_US
dc.authorid0000-0003-3815-1667en_US
dc.authorid0000-0002-3308-5843en_US
dc.contributor.authorÖzer, Muhammet Raşit
dc.contributor.authorErgin, Mehmet
dc.contributor.authorKılınç, İbrahim
dc.contributor.authorDündar, Zerrin Defne
dc.contributor.authorÖzer, Nejla
dc.contributor.authorÖnal, Mehmet Akif
dc.contributor.authorGirişgin, Abdullah Sadık
dc.contributor.authorKoçak, Sedat
dc.contributor.authorGül, Mehmet
dc.contributor.authorCander, Başar
dc.date.accessioned2020-01-18T21:02:50Z
dc.date.available2020-01-18T21:02:50Z
dc.date.issued2017
dc.departmentNEÜ, Meram Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Acil Tıp Anabilim Dalıen_US
dc.departmentNEÜ, Meram Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Anabilim Dalıen_US
dc.description.abstractAim: The aim was to evaluate the levels of serum pentraxin-3 (PTX-3) and neutrophil gelatinase-associated lipocalin (NGAL) and the efficiency of making a diagnosis and to estimate the prognosis in patients with chest pain.Materials and Methods: The study was conducted in the Necmettin Erbakan University Meram Medicine School Emergency Department. Patients who had chest pain and met the inclusion criteria were accepted. They were divided into the following groups: acute coronary syndrome (ACS), a diagnosis other than ACS (non-ACS), and control. The patients in theACS and non-ACS groups were divided into five sub-group -groups: ST Elevated Myocardial Infarction (STEMI) Non- ST Elevated Myocardial Infarction (NSTEMI), Unstable Angina Pectoris (USAP), stable angina, and pulmonary embolus. For all patients, serum PTX-3, serum NGAL, troponin I, and creatine kinase-MB fraction (CK-MB) levels were measured.Results: There were 199 patients in the ACS and non-ACS groups and 30 patientsin the control group. There was no significant difference among the study groups in terms of age and PTX-3 and NGAL levels. When comparing survival and non-survival in terms of in-hospital death, CK-MB and troponin I levels were significantly higher in the ACS and non-ACS groups than in the control groups, whereas there was no significant difference in terms of PTX-3 and NGAL levels.Conclusion: The results of our study demonstrated that PTX-3 and NGAL are not effective biomarkers in the differential diagnosis and the determination of in-hospital mortality in ACS. However, the limitations of the study should be considered. The results confirmed that CK-MB and Troponin I can be safely used in the differential diagnosis and the prediction of mortality.en_US
dc.identifier.citationOzer, M. R., Ergin, M., Kilinc, I., Dundar, Z. D., Ozer, N., Onal, M. A., Girisgin, A. S., Kocak, S., Gul, M., Cander, B. (2017). Diagnostic and Prognostic Significance of Neutrophil Gelatinase- Associated Lipocalin and Pentraxin-3 in Acute Coronary Syndrome. Eurasian Journal of Emergency Medicine, 16, 1, 12-18.en_US
dc.identifier.endpage18en_US
dc.identifier.issn2149-5807en_US
dc.identifier.issn2149-6048en_US
dc.identifier.issue1en_US
dc.identifier.startpage12en_US
dc.identifier.urihttp://app.trdizin.gov.tr/publication/paper/detail/TWpJek5EUTFOUT09
dc.identifier.urihttps://hdl.handle.net/20.500.12452/1304
dc.identifier.volume16en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofEurasian Journal of Emergency Medicineen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US]
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcil Tıpen_US
dc.subjectAcute Coronary Syndromeen_US
dc.subjectBiomarkeren_US
dc.subjectNeutrophil Gelatinase-Associated Lipocalinen_US
dc.subjectPentraxin-3en_US
dc.titleDiagnostic and Prognostic Significance of Neutrophil Gelatinase- Associated Lipocalin and Pentraxin-3 in Acute Coronary Syndromeen_US
dc.typeArticleen_US

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