Serum Level of suPAR and YKL-40, a New Biomarker in Patients with Acute Myocardial Infarction?
Yükleniyor...
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Introduction: Low grade inflammation plays an important role in the several development process of coronary artery disease. The soluble urokinase plasminogen activator receptor (suPAR) and chitinase 3-like protein 1 (YKL-40) are the new potential biomarkers of inflammation. We intended to test the hypothesis whether the inflammatory biomarker YKL-40 alone or in combination with suPAR could be the new diagnostic biomarkers for acute myocardial infarction (AMI). Material and Methods: Fifty-five patients with AMI and seventy control subjects were included in the study. The diagnosis of AMI was based on the current 3rd standard universal definition criteria. Serum YKL-40 and suPAR levels were measured at the first and second days of AMI by using ELİSA method. Results: Serum YKL-40 levels were significantly higher in the first (69.10 16.58 ng/mL) and second day (60.64 16.01 ng/mL) of AMI patients than those of the control subjects (37.11 4.30 ng/mL) (p0.001). Serum YKL-40 levels in the first day of AMI patients also were significantly higher than those of second day of AMI patients (p0.01). Serum suPAR were significantly higher in the first (6.58 3.24 ng/mL) and second day (5.86 4.56 ng/mL) of AMI patients than those of the control subjects (2.26 1.92 ng/mL) (p0.001). Conclusion: Serum suPAR and YKL-40 can be considered strong inflammatory markers of AMI. We concluded that serum suPAR and YKL-40 levels at the first day and second day of AMI could be used as a clinically useful marker for diagnosis of AMI.
Açıklama
Anahtar Kelimeler
Inflammation, The inflammatory biomarker, Ischemic heart disease
Kaynak
Acta Medica Anatolia
WoS Q Değeri
Scopus Q Değeri
Cilt
3
Sayı
4
Künye
Arıbaş A., Can, Ü., Yerlikaya, F. H., Toker, A., Akbuğa, K. (2015). Serum level of suPAR and YKL-40, a new biomarker in patients with acute myocardial infarction?. Acta Medica Anatolia, 3, 4, 137-143.
