Role of ChREBP and SREBP-1c in gestational diabetes: two key players in glucose and lipid metabolism
Küçük Resim Yok
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer India
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background Gestational diabetes mellitus (GDM) is any degree of glucose intolerance diagnosed during pregnancy. Metabolic abnormalities in GDM are associated with pancreatic beta-cell destruction and decreased insulin sensitivity. Carbohydrate-responsive element-binding protein (ChREBP) and sterol regulatory element-binding protein-1c (SREBP-1c) are two transcription factors that play a key role in carbohydrate and lipid metabolism homeostasis. Our aim in this study was to elucidate the role of these proteins in GDM. Methods The study included 50 pregnant women diagnosed with GDM and 52 pregnant women with normal glucose tolerance. Maternal blood samples were collected from pregnant women between the 24th and 28th weeks of pregnancy. Serum SREBP-1c and ChREBP levels were measured with commercial ELISA kits according to the manufacturer's instructions. Results Serum ChREBP (p=0.044) and SREBP1c (p=0.042) levels of pregnant women with normal glucose tolerance were found to be statistically significantly higher than women with GDM.
Açıklama
Anahtar Kelimeler
Gestational Diabetes, Insulin Resistance, Srebp-1c, Chrebp, Lipid Metabolism
Kaynak
International Journal Of Diabetes In Developing Countries
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
43
Sayı
4
