Role of ChREBP and SREBP-1c in gestational diabetes: two key players in glucose and lipid metabolism

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dc.contributor.authorEroglu, Nurgul
dc.contributor.authorYerlikaya, Fatma Humeyra
dc.contributor.authorOnmaz, Duygu Eryavuz
dc.contributor.authorColakoglu, Mehmet Cengiz
dc.date.accessioned2024-02-23T14:00:09Z
dc.date.available2024-02-23T14:00:09Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractBackground Gestational diabetes mellitus (GDM) is any degree of glucose intolerance diagnosed during pregnancy. Metabolic abnormalities in GDM are associated with pancreatic beta-cell destruction and decreased insulin sensitivity. Carbohydrate-responsive element-binding protein (ChREBP) and sterol regulatory element-binding protein-1c (SREBP-1c) are two transcription factors that play a key role in carbohydrate and lipid metabolism homeostasis. Our aim in this study was to elucidate the role of these proteins in GDM. Methods The study included 50 pregnant women diagnosed with GDM and 52 pregnant women with normal glucose tolerance. Maternal blood samples were collected from pregnant women between the 24th and 28th weeks of pregnancy. Serum SREBP-1c and ChREBP levels were measured with commercial ELISA kits according to the manufacturer's instructions. Results Serum ChREBP (p=0.044) and SREBP1c (p=0.042) levels of pregnant women with normal glucose tolerance were found to be statistically significantly higher than women with GDM.en_US
dc.description.sponsorshipNecmettin Erbakan University Scientific Research Projects Coordinator [191318004]en_US
dc.description.sponsorshipThis work was supported by the Necmettin Erbakan University Scientific Research Projects Coordinator under Grant Number 191318004.en_US
dc.identifier.doi10.1007/s13410-022-01050-x
dc.identifier.endpage591en_US
dc.identifier.issn0973-3930
dc.identifier.issn1998-3832
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85126033161en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage587en_US
dc.identifier.urihttps://doi.org/10.1007/s13410-022-01050-x
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11457
dc.identifier.volume43en_US
dc.identifier.wosWOS:000767030500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Indiaen_US
dc.relation.ispartofInternational Journal Of Diabetes In Developing Countriesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGestational Diabetesen_US
dc.subjectInsulin Resistanceen_US
dc.subjectSrebp-1cen_US
dc.subjectChrebpen_US
dc.subjectLipid Metabolismen_US
dc.titleRole of ChREBP and SREBP-1c in gestational diabetes: two key players in glucose and lipid metabolismen_US
dc.typeArticleen_US

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