Electrochemical monitoring of biointeraction by graphene-based material modified pencil graphite electrode

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dc.contributor.authorEksin, Ece
dc.contributor.authorZor, Erhan
dc.contributor.authorErdem, Arzum
dc.contributor.authorBingol, Haluk
dc.date.accessioned2024-02-23T14:02:16Z
dc.date.available2024-02-23T14:02:16Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractRecently, the low-cost effective biosensing systems based on advanced nanomaterials have received a key attention for development of novel assays for rapid and sequence-specific nucleic acid detection. The electrochemical biosensor based on reduced graphene oxide (rGO) modified disposable pencil graphite electrodes (PGEs) were developed herein for electrochemical monitoring of DNA, and also for monitoring of biointeraction occurred between anticancer drug, Daunorubicin (DNR), and DNA. First, rGO was synthesized chemically and characterized by using UV-Vis, TGA, FT-IR, Raman Spectroscopy and SEM techniques. Then, the quantity of rGO assembling onto the surface of PGE by passive adsorption was optimized. The electrochemical behavior of rGO PGEs was examined by cyclic voltammetry (CV). rGO-PGEs were then utilized for electrochemical monitoring of surface-confined interaction between DNR and DNA using differential pulse voltammetry (DPV) technique. Additionally, voltammetric results were complemented with electrochemical impedance spectroscopy (EIS) technique. Electrochemical monitoring of DNR and DNA was resulted with satisfying detection limits 0.55 mu M and 2.71 mu g/mL, respectively.en_US
dc.description.sponsorshipTurkish Academy of Sciences (TUBA)en_US
dc.description.sponsorshipA.E. would like to express her gratitude to the Turkish Academy of Sciences (TUBA) as an Principal member for its partial support.en_US
dc.identifier.doi10.1016/j.bios.2017.02.016
dc.identifier.endpage214en_US
dc.identifier.issn0956-5663
dc.identifier.issn1873-4235
dc.identifier.pmid28214748en_US
dc.identifier.scopus2-s2.0-85012980534en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage207en_US
dc.identifier.urihttps://doi.org/10.1016/j.bios.2017.02.016
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11648
dc.identifier.volume92en_US
dc.identifier.wosWOS:000396946600030en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Advanced Technologyen_US
dc.relation.ispartofBiosensors & Bioelectronicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectReduced Graphene Oxideen_US
dc.subjectPencil Graphite Electrodesen_US
dc.subjectElectrochemical Biosensorsen_US
dc.subjectDrug-Dna Interactionen_US
dc.subjectElectrochemical Impedance Spectroscopyen_US
dc.subjectDifferential Pulse Voltammetryen_US
dc.titleElectrochemical monitoring of biointeraction by graphene-based material modified pencil graphite electrodeen_US
dc.typeArticleen_US

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