Fetal Valproate Syndrome
Küçük Resim Yok
Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Taiwan
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: There have been several reports of congenital malformations in the offspring of mothers who took valproic acid (VPA) during pregnancy as a treatment for epilepsy. Methods: Herein, we describe four cases with typically similar facial features of fetal vatproate syndrome accompanied to minor skeletal abnormalities. Results: The first case was a 16-month-old girl, presenting with facial dysmorphism, and finger abnormalities. Her mother took VPA (1500 mg/d) up to the 10th gestational week and at a dosage of 1000 mg/d through the pregnancy. The second patient was 5-year-old boy with speech disability, bilateral cryptorchidism, facial dysmorphism, and finger abnormalities whose mother took VPA (1000 mg/d) through pregnancy. The third 19-month-old patient was the brother of the second patient who had facial dysmorphism, bilateral cryptorchidism, and finger abnormalities. His mother also took VPA (1000 mg/d) through pregnancy. The fourth 3-year and 6 month-old boy with minor facial dysmorphism and sternum deformity was exposed to VPA (500 mg/d) in utero. Conclusion: In conclusion, there is a recognizable spectrum of abnormalities in some infants exposed to VPA without dose-depence and the common facial dysmorphic features and minor skeletal abnormalities that may occur within the both low and high dose VPA use. Copyright (C) 2016, Taiwan Pediatric Association. Published by Elsevier Taiwan LLC.
Açıklama
Anahtar Kelimeler
Facial Dysmorphism, Fetal Valproate Syndrome, Minor Birth Defects, Skeletal Abnormalities
Kaynak
Pediatrics And Neonatology
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
58
Sayı
2
